Iron stores, hepcidin, and aortic stiffness in individuals with hypertension

Luca Valenti, Alessandro Maloberti, Stefano Signorini, Marta Milano, Francesca Cesana, Fabrizio Cappellini, Paola Dongiovanni, Marianna Porzio, Francesco Soriano, Maura Brambilla, Giancarlo Cesana, Paolo Brambilla, Cristina Giannattasio, Silvia Fargion

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Background & Aims: Iron accumulation within the arterial wall has been hypothesized to promote atherosclerosis progression. Aim of this study was to evaluate whether the hormone hepcidin and iron stores are associated with arterial stiffness in subjects with essential hypertension. Methods: Circulating hepcidin, ferritin, and mutations in the hemochromatosis gene were compared between subjects included in the first vs. third tertile (n=284 each) of carotid-femoral pulse wave velocity (PWV) in an unselected cohort of patients with arterial hypertension. Results: At univariate logistic regression analysis, high PWV was associated with higher ferritin levels (p=0.010), but lower hepcidin (p=0.045), and hepcidin ferritin/ratio (p

Original languageEnglish
Article numbere0134635
JournalPLoS One
Issue number8
Publication statusPublished - Aug 5 2015

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)


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