Iron values and haematological parameters of cross-country skiers. Effect of iron and 5-methyltetrahydrofolic acid (Prefolic)* * Prefolic - 5-methyltetrahydrofolic acid - BioResearch S.p.A., Milan, Italy. supplementation

A. Pattini, V. Di Salvo, F. Schena, Cristina Le Grazie

Research output: Contribution to journalArticle

Abstract

Haematological parameters related to the iron and folate status of 55 male top level cross-country skiers were investigated. A ferritin level ≤64 μg/L was regarded as the threshold value to ascertain pre-latent iron deficiency. The athletes showing basal ferritin levels lower than 64 μg/L were further subdivided into Groups A and B, while subjects with ferritin levels above 64 μg/L were included in Group C. Group A was treated for 60 days with oral sodium ferric gluconate 230 mg/day. Group B received the same treatment as Group A, plus 50 mg/day of 5-methyltetrahydrofolic acid (5-MTHF) orally during the first 30 days. Group C received 50 mg/day of oral 5-MTHF for the first 30 days and every second day for the following 30 days. Fasting blood samples were taken prior to supplementation, after 15, 30 and 60 days of therapy, and on the 15th day after treatment withdrawal. Of the athletes, 80% showed basal ferritin levels lower than 64 μg/L, and of these as many as 40% showed a value lower than 20 μg/L, suggesting iron depletion. In Group B ferritin levels showed a significant increase (P <0.05) above baseline (from 20 ± 2.2 to 43 ± 4.4 μg/L), and the reticulocyte count increased significantly by Day 30. Groups B and C showed a significant increase in haemoglobin levels and of both serum and erythrocyte folates. This study suggests that the oral supplementation with high doses of Iron and 5-MTHF to athletes showing pre-latent iron deficiency is more effective than iron alone in improving haematological parameters related to iron status and erythropoiesis. High doses of 5-MTHF appeared to be effective in improving haemoglobin levels also in iron-repleted subjects.

Original languageEnglish
Pages (from-to)296-307
Number of pages12
JournalClinical Trials Journal
Volume25
Issue number5
Publication statusPublished - 1988

Fingerprint

Italy
Iron
Ferritins
Athletes
Folic Acid
Hemoglobins
Reticulocyte Count
5-methyltetrahydrofolate
Erythropoiesis
Fasting
Therapeutics
Erythrocytes
Serum

Keywords

  • 5-methyltetrahydrofolic acid
  • ferritin
  • haemoglobin
  • intra-erythrocyte folate
  • iron repletion
  • pre-latent iron deficiency
  • Skiers

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

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title = "Iron values and haematological parameters of cross-country skiers. Effect of iron and 5-methyltetrahydrofolic acid (Prefolic)* * Prefolic - 5-methyltetrahydrofolic acid - BioResearch S.p.A., Milan, Italy. supplementation",
abstract = "Haematological parameters related to the iron and folate status of 55 male top level cross-country skiers were investigated. A ferritin level ≤64 μg/L was regarded as the threshold value to ascertain pre-latent iron deficiency. The athletes showing basal ferritin levels lower than 64 μg/L were further subdivided into Groups A and B, while subjects with ferritin levels above 64 μg/L were included in Group C. Group A was treated for 60 days with oral sodium ferric gluconate 230 mg/day. Group B received the same treatment as Group A, plus 50 mg/day of 5-methyltetrahydrofolic acid (5-MTHF) orally during the first 30 days. Group C received 50 mg/day of oral 5-MTHF for the first 30 days and every second day for the following 30 days. Fasting blood samples were taken prior to supplementation, after 15, 30 and 60 days of therapy, and on the 15th day after treatment withdrawal. Of the athletes, 80{\%} showed basal ferritin levels lower than 64 μg/L, and of these as many as 40{\%} showed a value lower than 20 μg/L, suggesting iron depletion. In Group B ferritin levels showed a significant increase (P <0.05) above baseline (from 20 ± 2.2 to 43 ± 4.4 μg/L), and the reticulocyte count increased significantly by Day 30. Groups B and C showed a significant increase in haemoglobin levels and of both serum and erythrocyte folates. This study suggests that the oral supplementation with high doses of Iron and 5-MTHF to athletes showing pre-latent iron deficiency is more effective than iron alone in improving haematological parameters related to iron status and erythropoiesis. High doses of 5-MTHF appeared to be effective in improving haemoglobin levels also in iron-repleted subjects.",
keywords = "5-methyltetrahydrofolic acid, ferritin, haemoglobin, intra-erythrocyte folate, iron repletion, pre-latent iron deficiency, Skiers",
author = "A. Pattini and {Di Salvo}, V. and F. Schena and {Le Grazie}, Cristina",
year = "1988",
language = "English",
volume = "25",
pages = "296--307",
journal = "Clinical Trials Journal",
issn = "0009-9325",
publisher = "Elsevier BV",
number = "5",

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T1 - Iron values and haematological parameters of cross-country skiers. Effect of iron and 5-methyltetrahydrofolic acid (Prefolic)* * Prefolic - 5-methyltetrahydrofolic acid - BioResearch S.p.A., Milan, Italy. supplementation

AU - Pattini, A.

AU - Di Salvo, V.

AU - Schena, F.

AU - Le Grazie, Cristina

PY - 1988

Y1 - 1988

N2 - Haematological parameters related to the iron and folate status of 55 male top level cross-country skiers were investigated. A ferritin level ≤64 μg/L was regarded as the threshold value to ascertain pre-latent iron deficiency. The athletes showing basal ferritin levels lower than 64 μg/L were further subdivided into Groups A and B, while subjects with ferritin levels above 64 μg/L were included in Group C. Group A was treated for 60 days with oral sodium ferric gluconate 230 mg/day. Group B received the same treatment as Group A, plus 50 mg/day of 5-methyltetrahydrofolic acid (5-MTHF) orally during the first 30 days. Group C received 50 mg/day of oral 5-MTHF for the first 30 days and every second day for the following 30 days. Fasting blood samples were taken prior to supplementation, after 15, 30 and 60 days of therapy, and on the 15th day after treatment withdrawal. Of the athletes, 80% showed basal ferritin levels lower than 64 μg/L, and of these as many as 40% showed a value lower than 20 μg/L, suggesting iron depletion. In Group B ferritin levels showed a significant increase (P <0.05) above baseline (from 20 ± 2.2 to 43 ± 4.4 μg/L), and the reticulocyte count increased significantly by Day 30. Groups B and C showed a significant increase in haemoglobin levels and of both serum and erythrocyte folates. This study suggests that the oral supplementation with high doses of Iron and 5-MTHF to athletes showing pre-latent iron deficiency is more effective than iron alone in improving haematological parameters related to iron status and erythropoiesis. High doses of 5-MTHF appeared to be effective in improving haemoglobin levels also in iron-repleted subjects.

AB - Haematological parameters related to the iron and folate status of 55 male top level cross-country skiers were investigated. A ferritin level ≤64 μg/L was regarded as the threshold value to ascertain pre-latent iron deficiency. The athletes showing basal ferritin levels lower than 64 μg/L were further subdivided into Groups A and B, while subjects with ferritin levels above 64 μg/L were included in Group C. Group A was treated for 60 days with oral sodium ferric gluconate 230 mg/day. Group B received the same treatment as Group A, plus 50 mg/day of 5-methyltetrahydrofolic acid (5-MTHF) orally during the first 30 days. Group C received 50 mg/day of oral 5-MTHF for the first 30 days and every second day for the following 30 days. Fasting blood samples were taken prior to supplementation, after 15, 30 and 60 days of therapy, and on the 15th day after treatment withdrawal. Of the athletes, 80% showed basal ferritin levels lower than 64 μg/L, and of these as many as 40% showed a value lower than 20 μg/L, suggesting iron depletion. In Group B ferritin levels showed a significant increase (P <0.05) above baseline (from 20 ± 2.2 to 43 ± 4.4 μg/L), and the reticulocyte count increased significantly by Day 30. Groups B and C showed a significant increase in haemoglobin levels and of both serum and erythrocyte folates. This study suggests that the oral supplementation with high doses of Iron and 5-MTHF to athletes showing pre-latent iron deficiency is more effective than iron alone in improving haematological parameters related to iron status and erythropoiesis. High doses of 5-MTHF appeared to be effective in improving haemoglobin levels also in iron-repleted subjects.

KW - 5-methyltetrahydrofolic acid

KW - ferritin

KW - haemoglobin

KW - intra-erythrocyte folate

KW - iron repletion

KW - pre-latent iron deficiency

KW - Skiers

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