Irradiated fields spared Stevens-Johnson syndrome in a patient undergoing radiotherapy for bone metastases

Daniela Musio; Elisabetta Parisi; Francesco Dionisi; Giuseppe Parisi; Rossella Caiazzo; Nadia Bulzonetti; Miriam Lichtner; Nicola Raffetto; Vincenzo Vullo; Enzo Banelli

doi:10.1007/s11604-008-0297-9

Irradiated fields spared Stevens-Johnson syndrome in a patient undergoing radiotherapy for bone metastases

Daniela Musio, Elisabetta Parisi, Francesco Dionisi, Giuseppe Parisi, Rossella Caiazzo, Nadia Bulzonetti, Miriam Lichtner, Nicola Raffetto, Vincenzo Vullo, Enzo Banelli

Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori

Research output: Contribution to journal › Article › peer-review

Abstract

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are two of the most severe, rare, and life-threatening adverse reactions to medications. Their incidence is approximately two patients per million population per year. Several cases have been reported in the literature in which SJS and TEN have occurred in patients with a neoplasm undergoing radiation therapy and who are taking an anticonvulsant. We report a case of SJS-TEN that developed in a 51-year-old woman with nonresectable non-small-cell lung cancer during treatment with phenobarbital plus radiation therapy for bone metastases but in whom the irradiated areas did not exhibit the SJS skin reaction. To our knowledge, no similar cases have been reported in the literature.

Original language	English
Pages (from-to)	103-106
Number of pages	4
Journal	Japanese Journal of Radiology
Volume	27
Issue number	2
DOIs	https://doi.org/10.1007/s11604-008-0297-9
Publication status	Published - Feb 2009

Keywords

Phenobarbital
Radiotherapy
Skin reaction
Spared fields
Stevens-Johnson syndrome

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1007/s11604-008-0297-9

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Irradiated fields spared Stevens-Johnson syndrome in a patient undergoing radiotherapy for bone metastases. / Musio, Daniela; Parisi, Elisabetta; Dionisi, Francesco; Parisi, Giuseppe; Caiazzo, Rossella; Bulzonetti, Nadia; Lichtner, Miriam; Raffetto, Nicola; Vullo, Vincenzo; Banelli, Enzo.

In: Japanese Journal of Radiology, Vol. 27, No. 2, 02.2009, p. 103-106.

Research output: Contribution to journal › Article › peer-review

Musio, Daniela ; Parisi, Elisabetta ; Dionisi, Francesco ; Parisi, Giuseppe ; Caiazzo, Rossella ; Bulzonetti, Nadia ; Lichtner, Miriam ; Raffetto, Nicola ; Vullo, Vincenzo ; Banelli, Enzo. / Irradiated fields spared Stevens-Johnson syndrome in a patient undergoing radiotherapy for bone metastases. In: Japanese Journal of Radiology. 2009 ; Vol. 27, No. 2. pp. 103-106.

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abstract = "Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are two of the most severe, rare, and life-threatening adverse reactions to medications. Their incidence is approximately two patients per million population per year. Several cases have been reported in the literature in which SJS and TEN have occurred in patients with a neoplasm undergoing radiation therapy and who are taking an anticonvulsant. We report a case of SJS-TEN that developed in a 51-year-old woman with nonresectable non-small-cell lung cancer during treatment with phenobarbital plus radiation therapy for bone metastases but in whom the irradiated areas did not exhibit the SJS skin reaction. To our knowledge, no similar cases have been reported in the literature.",

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AU - Musio, Daniela

AU - Parisi, Elisabetta

AU - Dionisi, Francesco

AU - Parisi, Giuseppe

AU - Caiazzo, Rossella

AU - Bulzonetti, Nadia

AU - Lichtner, Miriam

AU - Raffetto, Nicola

AU - Vullo, Vincenzo

AU - Banelli, Enzo

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N2 - Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are two of the most severe, rare, and life-threatening adverse reactions to medications. Their incidence is approximately two patients per million population per year. Several cases have been reported in the literature in which SJS and TEN have occurred in patients with a neoplasm undergoing radiation therapy and who are taking an anticonvulsant. We report a case of SJS-TEN that developed in a 51-year-old woman with nonresectable non-small-cell lung cancer during treatment with phenobarbital plus radiation therapy for bone metastases but in whom the irradiated areas did not exhibit the SJS skin reaction. To our knowledge, no similar cases have been reported in the literature.

AB - Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are two of the most severe, rare, and life-threatening adverse reactions to medications. Their incidence is approximately two patients per million population per year. Several cases have been reported in the literature in which SJS and TEN have occurred in patients with a neoplasm undergoing radiation therapy and who are taking an anticonvulsant. We report a case of SJS-TEN that developed in a 51-year-old woman with nonresectable non-small-cell lung cancer during treatment with phenobarbital plus radiation therapy for bone metastases but in whom the irradiated areas did not exhibit the SJS skin reaction. To our knowledge, no similar cases have been reported in the literature.

KW - Phenobarbital

KW - Radiotherapy

KW - Skin reaction

KW - Spared fields

KW - Stevens-Johnson syndrome

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Irradiated fields spared Stevens-Johnson syndrome in a patient undergoing radiotherapy for bone metastases

Abstract

Keywords

ASJC Scopus subject areas

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