Irradiated fields spared Stevens-Johnson syndrome in a patient undergoing radiotherapy for bone metastases

Daniela Musio, Elisabetta Parisi, Francesco Dionisi, Giuseppe Parisi, Rossella Caiazzo, Nadia Bulzonetti, Miriam Lichtner, Nicola Raffetto, Vincenzo Vullo, Enzo Banelli

Research output: Contribution to journalArticle

Abstract

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are two of the most severe, rare, and life-threatening adverse reactions to medications. Their incidence is approximately two patients per million population per year. Several cases have been reported in the literature in which SJS and TEN have occurred in patients with a neoplasm undergoing radiation therapy and who are taking an anticonvulsant. We report a case of SJS-TEN that developed in a 51-year-old woman with nonresectable non-small-cell lung cancer during treatment with phenobarbital plus radiation therapy for bone metastases but in whom the irradiated areas did not exhibit the SJS skin reaction. To our knowledge, no similar cases have been reported in the literature.

Original languageEnglish
Pages (from-to)103-106
Number of pages4
JournalJapanese Journal of Radiology
Volume27
Issue number2
DOIs
Publication statusPublished - Feb 2009

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Keywords

  • Phenobarbital
  • Radiotherapy
  • Skin reaction
  • Spared fields
  • Stevens-Johnson syndrome

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Musio, D., Parisi, E., Dionisi, F., Parisi, G., Caiazzo, R., Bulzonetti, N., Lichtner, M., Raffetto, N., Vullo, V., & Banelli, E. (2009). Irradiated fields spared Stevens-Johnson syndrome in a patient undergoing radiotherapy for bone metastases. Japanese Journal of Radiology, 27(2), 103-106. https://doi.org/10.1007/s11604-008-0297-9