Irreversible disability and tissue loss in multiple sclerosis: A conventional and magnetization transfer magnetic resonance imaging study of the optic nerves

Matilde Inglese, Angelo Ghezzi, Stefania Bianchi, Simonetta Gerevini, Maria Pia Sormani, Vittorio Martinelli, Giancarlo Comi, Massimo Filippi

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: To assess, by magnetic resonance imaging, the volumes and magnetization transfer ratio (MTR) values of optic nerves (ONs) from patients with multiple sclerosis (MS) who had incomplete or no visual recovery after optic neuritis; and to compare these quantities with those derived from ONs from patients with MS who showed a marked clinical recovery after optic neuritis, ONs from healthy volunteers, and ONs from patients with Leber hereditary optic neuropathy (LHON). Methods: Conventional and magnetization transfer magnetic resonance images of the ONs were obtained from 30 patients with MS, 18 healthy volunteers, and 10 patients with LHON. The ON from patients with MS were classified as clinically unaffected (n = 18); clinically affected with recovery (n = 20; visual acuity ≥20/25 at least 6 months after optic neuritis); and clinically affected with incomplete or no recovery (n = 22; visual acuity

Original languageEnglish
Pages (from-to)250-255
Number of pages6
JournalArchives of Neurology
Volume59
Issue number2
Publication statusPublished - 2002

ASJC Scopus subject areas

  • Neuroscience(all)

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