Irreversible intestinal failure: Prevalence and prognostic factors

Antonella Diamanti, Maria Sole Basso, Massimo Castro, Vincenzo Di Ciommo, Fiammetta Bracci, Francesca Ferretti, Andrea Pietrobattista, Manuela Gambarara

Research output: Contribution to journalArticlepeer-review


Background and Aim: Parenteral nutrition (PN) is the primary treatment for intestinal failure, which is considered irreversible in patientswho remain partially or fully dependent on PN. Causes of irreversible intestinal failure are short bowel syndrome (SBS), motility disorders (MD), and severe protracted diarrhea (SPD). The aim of this study was to report the clinical outcome in these patients in relation to the underlying disease. Patients and Methods: From January 1, 1989 to December 31, 2006, 218 intestinal failure patients were observed in our center, but only 96 (48 SBS, 39 SPD, and 9 MD) were included because they required at least 50% of their total calories as PN for not less than 3 months. In these patients, survival and complication rates were evaluated. Results: The survival rate was significantly higher in SBS patients than in the other groups (P

Original languageEnglish
Pages (from-to)450-457
Number of pages8
JournalJournal of Pediatric Gastroenterology and Nutrition
Issue number4
Publication statusPublished - Oct 2008


  • Intestinal failure
  • Motility disorders
  • Parenteral nutrition
  • Severe diarrhea
  • Short bowel syndrome

ASJC Scopus subject areas

  • Gastroenterology
  • Pediatrics, Perinatology, and Child Health


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