IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy

Georgia Hatzivassiliou; Ira Miller; Jun Takizawa; Nallasivam Palanisamy; Pulivarthi H. Rao; Shinsuke Iida; Shinichi Tagawa; Masafumi Taniwaki; James Russo; Antonino Neri; Giorgio Cattoretti; Raphael Clynes; Cathy Mendelsohn; R. S K Chaganti; Riccardo Dalla-Favera

doi:10.1016/S1074-7613(01)00109-1

IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy

Georgia Hatzivassiliou, Ira Miller, Jun Takizawa, Nallasivam Palanisamy, Pulivarthi H. Rao, Shinsuke Iida, Shinichi Tagawa, Masafumi Taniwaki, James Russo, Antonino Neri, Giorgio Cattoretti, Raphael Clynes, Cathy Mendelsohn, R. S K Chaganti, Riccardo Dalla-Favera

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

Abnormalities of chromosome 1q21 are common in B cell malignancies, but their target genes are largely unknown. By cloning the breakpoints of a (1;14) (q21;q32) chromosomal translocation in a myeloma cell line, we have identified two novel genes, IRTA1 and IRTA2, encoding cell surface receptors homologous to the Fc and inhibitory receptor families. Both genes are selectively expressed in mature B cells: IRTA1 in marginal zone B cells and IRTA2 in centrocytes, marginal zone B cells, and immunoblasts. As a result of the t(1;14), IRTA1 is fused to the immunoglobulin Cα domain to produce a chimeric IRTA1/Cα fusion protein. In tumor cell lines with 1q21 abnormalities, IRTA2 expression is deregulated. Thus, IRTA1 and IRTA2 are novel immunoreceptors implicated in B cell development and lymphomagenesis.

Original language	English
Pages (from-to)	277-289
Number of pages	13
Journal	Immunity
Volume	14
Issue number	3
DOIs	https://doi.org/10.1016/S1074-7613(01)00109-1
Publication status	Published - 2001

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases
Immunology

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Hatzivassiliou, G., Miller, I., Takizawa, J., Palanisamy, N., Rao, P. H., Iida, S., Tagawa, S., Taniwaki, M., Russo, J., Neri, A., Cattoretti, G., Clynes, R., Mendelsohn, C., Chaganti, R. S. K., & Dalla-Favera, R. (2001). IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy. Immunity, 14(3), 277-289. https://doi.org/10.1016/S1074-7613(01)00109-1

IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy. / Hatzivassiliou, Georgia; Miller, Ira; Takizawa, Jun; Palanisamy, Nallasivam; Rao, Pulivarthi H.; Iida, Shinsuke; Tagawa, Shinichi; Taniwaki, Masafumi; Russo, James; Neri, Antonino; Cattoretti, Giorgio; Clynes, Raphael; Mendelsohn, Cathy; Chaganti, R. S K; Dalla-Favera, Riccardo.

In: Immunity, Vol. 14, No. 3, 2001, p. 277-289.

Research output: Contribution to journal › Article › peer-review

Hatzivassiliou, G, Miller, I, Takizawa, J, Palanisamy, N, Rao, PH, Iida, S, Tagawa, S, Taniwaki, M, Russo, J, Neri, A, Cattoretti, G, Clynes, R, Mendelsohn, C, Chaganti, RSK & Dalla-Favera, R 2001, 'IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy', Immunity, vol. 14, no. 3, pp. 277-289. https://doi.org/10.1016/S1074-7613(01)00109-1

Hatzivassiliou, Georgia ; Miller, Ira ; Takizawa, Jun ; Palanisamy, Nallasivam ; Rao, Pulivarthi H. ; Iida, Shinsuke ; Tagawa, Shinichi ; Taniwaki, Masafumi ; Russo, James ; Neri, Antonino ; Cattoretti, Giorgio ; Clynes, Raphael ; Mendelsohn, Cathy ; Chaganti, R. S K ; Dalla-Favera, Riccardo. / IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy. In: Immunity. 2001 ; Vol. 14, No. 3. pp. 277-289.

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abstract = "Abnormalities of chromosome 1q21 are common in B cell malignancies, but their target genes are largely unknown. By cloning the breakpoints of a (1;14) (q21;q32) chromosomal translocation in a myeloma cell line, we have identified two novel genes, IRTA1 and IRTA2, encoding cell surface receptors homologous to the Fc and inhibitory receptor families. Both genes are selectively expressed in mature B cells: IRTA1 in marginal zone B cells and IRTA2 in centrocytes, marginal zone B cells, and immunoblasts. As a result of the t(1;14), IRTA1 is fused to the immunoglobulin Cα domain to produce a chimeric IRTA1/Cα fusion protein. In tumor cell lines with 1q21 abnormalities, IRTA2 expression is deregulated. Thus, IRTA1 and IRTA2 are novel immunoreceptors implicated in B cell development and lymphomagenesis.",

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AU - Palanisamy, Nallasivam

AU - Rao, Pulivarthi H.

AU - Iida, Shinsuke

AU - Tagawa, Shinichi

AU - Taniwaki, Masafumi

AU - Russo, James

AU - Neri, Antonino

AU - Cattoretti, Giorgio

AU - Clynes, Raphael

AU - Mendelsohn, Cathy

AU - Chaganti, R. S K

AU - Dalla-Favera, Riccardo

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N2 - Abnormalities of chromosome 1q21 are common in B cell malignancies, but their target genes are largely unknown. By cloning the breakpoints of a (1;14) (q21;q32) chromosomal translocation in a myeloma cell line, we have identified two novel genes, IRTA1 and IRTA2, encoding cell surface receptors homologous to the Fc and inhibitory receptor families. Both genes are selectively expressed in mature B cells: IRTA1 in marginal zone B cells and IRTA2 in centrocytes, marginal zone B cells, and immunoblasts. As a result of the t(1;14), IRTA1 is fused to the immunoglobulin Cα domain to produce a chimeric IRTA1/Cα fusion protein. In tumor cell lines with 1q21 abnormalities, IRTA2 expression is deregulated. Thus, IRTA1 and IRTA2 are novel immunoreceptors implicated in B cell development and lymphomagenesis.

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IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy

Abstract

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