Abstract
Purpose: β2-microglobulin amyloidosis (Aβ2M) is one of the main long-term complications of dialysis treatment. The incidence and the onset of Aβ2M has been related to membrane composition and/or dialysis technique, with non-homogeneous results. This study was carried out to detect: i) the incidence of bone cysts and CTS from Aβ2M; ii) the difference in Aβ 2M onset between cellulosic and synthetic membranes; iii) other risk factors besides the membrane. Methods: 480 HD patients were selected between 1986 to 2005 and grouped according to the 4 types of membranes used (cellulose, synthetically modified cellulose, synthetic low-flux, synthetic high-flux). The patients were analyzed before and after 1995, when the reverse osmosis treatment for dialysis water was started at our center, and the incidence of Aβ2M was compared between the two periods. Routine plain radiography, computer tomography (CT) and nuclear magnetic resonance imaging (MRI) as well as electromyography were used to investigate the clinical symptoms. Results: Bone cysts occurred in 29.2% of patients before 1995 vs. 12.2% after 1995 (p2M. Conclusions: The findings that the inflammatory status as well as low albumin and the residual GFR of the uremic patient are predictive of Aβ2M lesions suggests that Aβ2M has a multifactorial origin rather than being solely a membrane- or technique-related side effect.
| Original language | English |
|---|---|
| Pages (from-to) | 864-878 |
| Number of pages | 15 |
| Journal | International Journal of Artificial Organs |
| Volume | 30 |
| Issue number | 10 |
| Publication status | Published - Oct 2007 |
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Keywords
- β2-microglobulin amyloidosis
- Bone cysts
- Carpal tunnel syndrom
- Cellulosic membranes
- Dialysis
- Synthetic membranes
ASJC Scopus subject areas
- Biophysics
Cite this
Is β2-microglobulin-related amyloidosis of hemodialysis patients a multifactorial disease? A new pathogenetic approach. / Cianciolo, G.; Colì, L.; La Manna, G.; Donati, G.; D'Addio, F.; Comai, G.; Ricci, D.; Dormi, A.; Wratten, M.; Feliciangeli, G.; Stefoni, Sergio.
In: International Journal of Artificial Organs, Vol. 30, No. 10, 10.2007, p. 864-878.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Is β2-microglobulin-related amyloidosis of hemodialysis patients a multifactorial disease? A new pathogenetic approach
AU - Cianciolo, G.
AU - Colì, L.
AU - La Manna, G.
AU - Donati, G.
AU - D'Addio, F.
AU - Comai, G.
AU - Ricci, D.
AU - Dormi, A.
AU - Wratten, M.
AU - Feliciangeli, G.
AU - Stefoni, Sergio
PY - 2007/10
Y1 - 2007/10
N2 - Purpose: β2-microglobulin amyloidosis (Aβ2M) is one of the main long-term complications of dialysis treatment. The incidence and the onset of Aβ2M has been related to membrane composition and/or dialysis technique, with non-homogeneous results. This study was carried out to detect: i) the incidence of bone cysts and CTS from Aβ2M; ii) the difference in Aβ 2M onset between cellulosic and synthetic membranes; iii) other risk factors besides the membrane. Methods: 480 HD patients were selected between 1986 to 2005 and grouped according to the 4 types of membranes used (cellulose, synthetically modified cellulose, synthetic low-flux, synthetic high-flux). The patients were analyzed before and after 1995, when the reverse osmosis treatment for dialysis water was started at our center, and the incidence of Aβ2M was compared between the two periods. Routine plain radiography, computer tomography (CT) and nuclear magnetic resonance imaging (MRI) as well as electromyography were used to investigate the clinical symptoms. Results: Bone cysts occurred in 29.2% of patients before 1995 vs. 12.2% after 1995 (p2M. Conclusions: The findings that the inflammatory status as well as low albumin and the residual GFR of the uremic patient are predictive of Aβ2M lesions suggests that Aβ2M has a multifactorial origin rather than being solely a membrane- or technique-related side effect.
AB - Purpose: β2-microglobulin amyloidosis (Aβ2M) is one of the main long-term complications of dialysis treatment. The incidence and the onset of Aβ2M has been related to membrane composition and/or dialysis technique, with non-homogeneous results. This study was carried out to detect: i) the incidence of bone cysts and CTS from Aβ2M; ii) the difference in Aβ 2M onset between cellulosic and synthetic membranes; iii) other risk factors besides the membrane. Methods: 480 HD patients were selected between 1986 to 2005 and grouped according to the 4 types of membranes used (cellulose, synthetically modified cellulose, synthetic low-flux, synthetic high-flux). The patients were analyzed before and after 1995, when the reverse osmosis treatment for dialysis water was started at our center, and the incidence of Aβ2M was compared between the two periods. Routine plain radiography, computer tomography (CT) and nuclear magnetic resonance imaging (MRI) as well as electromyography were used to investigate the clinical symptoms. Results: Bone cysts occurred in 29.2% of patients before 1995 vs. 12.2% after 1995 (p2M. Conclusions: The findings that the inflammatory status as well as low albumin and the residual GFR of the uremic patient are predictive of Aβ2M lesions suggests that Aβ2M has a multifactorial origin rather than being solely a membrane- or technique-related side effect.
KW - β2-microglobulin amyloidosis
KW - Bone cysts
KW - Carpal tunnel syndrom
KW - Cellulosic membranes
KW - Dialysis
KW - Synthetic membranes
UR - http://www.scopus.com/inward/record.url?scp=38149118856&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=38149118856&partnerID=8YFLogxK
M3 - Article
VL - 30
SP - 864
EP - 878
JO - International Journal of Artificial Organs
JF - International Journal of Artificial Organs
SN - 0391-3988
IS - 10
ER -