Is a clear benefit in survival enough to modify patient access to the surgery service? A retrospective analysis in a cohort of gastric cancer patients

Mattia Altini, Elisa Carretta, Paolo Morgagni, Tiziano Carradori, Emanuele Ciotti, Elena Prati, Domenico Garcea, Amadori Dino, Fabio Falcini, Oriana Nanni

Research output: Contribution to journalArticle

Abstract

Background: Surgery has become an important tool for cancer treatment, requiring many available resources and a good organization of the surgery service. The aim of this study was to provide robust data for policymakers on the impact of hospital volume on survival, taking into account different sources of information.

Methods: We performed a retrospective study in a cohort of patients with gastric cancer submitted to partial or total gastrectomy. Data for the analysis were retrieved from regional administrative databases, the regional death registry, and histological reports. The main outcome measures were operative mortality and long-term survival. The associations between hospital volume and risk of mortality were calculated using a Cox multiple regression analysis.

Results: The estimated relationship between operative mortality and volume was not statistically significant. Conversely, high-volume hospitals had an increased likelihood of long-term survival compared to low-volume institutions: hazard ratio 0.79 (95 % confidence interval, 0.66–0.94, p = 0.01). The percentage variation between crude and adjusted HRs using only administrative data or administrative and histological data was very small. However, the combined use of administrative and clinical data provided a more accurate model for estimating risk-adjusted mortality.

Conclusions: A positive association between hospital volume and survival was evident for long-term outcome after adjusting for patient and tumor confounding. Moreover, the patient’s choice of hospital was not guided by specific care pathways or screening programs, and prognosis was not poorer for patients in high-volume hospitals. These findings suggest that there is leeway for improving access to surgery for gastric cancer patients.

Original languageEnglish
Pages (from-to)159-166
Number of pages8
JournalGastric Cancer
Volume18
Issue number1
DOIs
Publication statusPublished - Dec 6 2014

Keywords

  • Gastrectomy
  • Gastric cancer
  • Hospital volume
  • Survival

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology
  • Cancer Research
  • Medicine(all)

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