Is a family history of diabetes associated with an increased level of cardiovascular risk factors? Studies in healthy people and in subjects with different degree of glucose intolerance

A. Quatraro, D. Giugliano, N. De Rosa, A. Minei, M. Ettorre, C. Donzella, F. Saccomanno, A. Ceriello

Research output: Contribution to journalArticle

Abstract

In order to evaluate whether the presence of a positive family history of diabetes (PFH) may have a negative impact on both glucose metabolism and cardiovascular risk factors, we studied parameters of carbohydrate metaholism (fasting and 2 h-plasma glucose, HbA1c) and beta-cell function (fasting insulin and C-peptide), as well as the levels of some established cardiovascular risk factors (total cholesterol and triglycerides, HDL-cholesterol, blood pressure) in 729 subjects who were seen within the frame of a Regional Health Program in Taranto, South Italy. According to the NDDG criteria, 147 men and 235 women had normal glucose tolerance, 54 men and 66 women non-diagnostic OGTT, 65 men and 79 women impaired glucose tolerance, and 45 men and 58 women newly-diagnosed Type 2 diabetes. There was a continuous increase of PFH across the categories of glucose intolerance (p <0.001). Subjects with PFH were younger (4 years on the average) than subjects without PFH. After adjustement for age, there was no difference in the clinical and metabolic parameters considered across the categories of glucose tolerance between subjects with or without PFH. Only in OGTT-diagnosed diabetics, was the presence of PFH associated with significantly greater levels of total cholesterol and 2h-plasma glucose, as well as a trend for triglycerides and HbA1c to be higher. There was a continuous increase in fasting glucose, HbA1c, insulin and C-peptide across the categories; however, the C-peptide/insulin molar ratio was lowest in OGTT-diagnosed diabetics. There was a graded and significant increase in the levels of cardiovascular risk factors across the categories. In subjects with normal glucose tolerance, there was a weak but significant correlation between HbA1c, systolic blood pressure (r = 0.13, p <0.01) and total cholesterol (r = 0.16, p <0.01). Thus, 1) the presence of PFH seems to be associated with earliest metabolic decompensation in OGTT-diagnosed diabetics; 2) even the earliest evidence of glucose intolerance is associated with increased levels of cardiovascular risk factors; and 3) the relationship between HbA1c and some established risk factors for cardiovascular diseases suggest that the contribution of chronic hyperglycaemia to the macrovascular disease of diabetics might be more important than previously thought to be.

Original languageEnglish
Pages (from-to)230-238
Number of pages9
JournalDiabete et Metabolisme
Volume19
Issue number2
Publication statusPublished - 1993

Keywords

  • cardiovascular risk factors
  • family history of diabetes
  • glucose intolerance
  • OGTT-diagnosed diabetes mellitus

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

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