Is acid relevant in the genesis of dyspeptic symptoms associated with nonerosive reflux disease?

Vincenzo Savarino, Edoardo Savarino

Research output: Contribution to journalArticlepeer-review


• The pathogenesis of dyspeptic symptoms in a subset of patients with nonerosive reflux disease (NERD) is still unclear. • A common pathophysiological factor has been hypothesized and gastric acid has been considered as the most plausible one. • This study concludes that dyspepsia associated with NERD is not related to acid, and the two conditions have to be considered and treated as two separate entities. A consistent subset of patients with NERD suffers from symptoms centered in the upper part of the abdomen that are more characteristic of functional dyspepsia than reflux disease. The cause of this overlap is still unclear, but acid has been implicated as one of the possible common pathophysiological factors responsible for these two categories of upper gastrointestinal (GI) symptoms. Many physiological investigations and the modest success of proton pump inhibitors in resolving dyspeptic symptoms associated with typical reflux syndrome seem to support the concept that functional dyspepsia and NERD are two separate entities, which need to be treated with different drugs.

Original languageEnglish
Pages (from-to)252-254
Number of pages3
JournalEuropean Journal of Gastroenterology and Hepatology
Issue number4
Publication statusPublished - Apr 2008


  • Acid secretion
  • Dyspeptic symptoms
  • Non-erosive reflux disease
  • Oesophago-gastric pH testing
  • PPI therapy

ASJC Scopus subject areas

  • Gastroenterology


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