Is acute recurrent pancreatitis a chronic disease?

Alberto Mariani, Pier Alberto Testoni

Research output: Contribution to journalArticlepeer-review


Whether acute recurrent pancreatitis is a chronic disease is still debated and a consensus is not still reached as demonstrated by differences in the classification of acute recurrent pancreatitis. There is major evidence for considering alcoholic pancreatitis as a chronic disease ab initio while chronic pancreatitis lesions detectable in biliary acute recurrent pancreatitis (ARP) seem a casual association. Cystic fibrosis transmembrane conductance regulator (CFTR) gene mutation, hereditary and obstructive pancreatitis seem an acute disease that progress to chronic pancreatitis, likely as a consequence of the activation and proliferation of pancreatic stellate cells that produce and activate collagen and therefore fibrosis. From the diagnostic point of view, in patients with acute recurrent pancreatitis Endoscopic ultrasound (EUS) seems the more reliable technique for an accurate evaluation and follow-up of some ductal and parenchymal abnormalities suspected for early chronic pancreatitis.

Original languageEnglish
Pages (from-to)995-998
Number of pages4
JournalWorld Journal of Gastroenterology
Issue number7
Publication statusPublished - Feb 21 2008


  • Acute recurrent pancreatitis
  • Alcoholic pancreatitis
  • Chronic pancreatitis
  • Classification of pancreatitis
  • Pancreatic stellate cells

ASJC Scopus subject areas

  • Gastroenterology


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