Is blood pleurodesis effective for determining the cessation of persistent air leak?

Anthony Chambers, Tom Routledge, Andrea Billè, Marco Scarci

Research output: Contribution to journalArticlepeer-review


A best evidence topic in thoracic surgery was written according to a structured protocol. The question addressed whether blood pleurodesis is effective for cessation of persistent air leak (PAL). Altogether more than 43 papers were found using the reported search, of which 10 represented the best evidence to answer the clinical question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated. We conclude that autologous blood pleurodesis has superior outcomes when compared with conservative management for treatment of postoperative PAL. In addition, for PAL causing pneumothorax, blood pleurodesis woptimal volume 100 ml (from two studies)x should be considered in patients who are unsuitable for surgery, talc pleurodesis is ineffective or not viable (including cases complicated by acute respiratory distress syndrome) and a prompt resolution is required. Some 70-81% of patients treated for postoperative air leak resolved within 12 h and 95-100% within 48 h vs. a mean of 3-6.3 days (from two studies) with simple drainage. Resolution of pneumothorax with blood pleurodesis was also significantly shorter (P

Original languageEnglish
Pages (from-to)468-472
Number of pages5
JournalInteractive Cardiovascular and Thoracic Surgery
Issue number4
Publication statusPublished - Oct 2010


  • Airleaks
  • Blood patch
  • Blood pleurodesis
  • Pneumothorax

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pulmonary and Respiratory Medicine
  • Surgery


Dive into the research topics of 'Is blood pleurodesis effective for determining the cessation of persistent air leak?'. Together they form a unique fingerprint.

Cite this