Is Carotid Plaque Contrast Enhancement on MRI Predictive for Cerebral or Cardiovascular Events? A Prospective Cohort Study

Giacomo Davide Edoardo Papini, Giovanni Di Leo, Michele Bandirali, Biagio Cotticelli, Nicola Flor, Pietro Restivo, Giovanni Nano, Francesco Sardanelli

Research output: Contribution to journalArticlepeer-review


OBJECTIVE: The aim of this study was to correlate carotid plaque contrast enhancement (CPCE) to onset of cerebral/cardiovascular events (CCVE) in patients with atherosclerotic carotid disease.

METHODS: The ethics committee approved this prospective study. Patients with carotid artery stenosis underwent magnetic resonance angiography before/after injection of 0.1 mmol/kg of gadobenate dimeglumine. Carotid plaque contrast enhancement was graded as follows: 0, no CPCE; 1, 1 single enhancement focus; 2, 2 or more foci.

RESULTS: Seventy-seven patients (71 ± 9 years) had a stenosis degree: 34 mild, 16 moderate, 27 severe at the right side, and 36, 15, and 25 at the left side. Carotid plaque contrast enhancement was 0 in 30 patients, 1 in 26, 2 in 11 at the right, and 37, 19, and 13 at the left. Forty-seven CCVE occurred after magnetic resonance imaging, correlated to both stenosis degree (P = 0.006) and CPCE (P = 0.032). Excluding surgery/stenting, the correlation held only for CPCE (P = 0.017). Of 49 patients showing CPCE, 5 (10%) reported CCVE; of 21 patients without CPCE, none reported CCVE (P = 0.129).

CONCLUSIONS: The absence of CPCE seems to be a negative predictor for CCVE.

Original languageEnglish
Pages (from-to)321-326
Number of pages6
JournalJournal of Computer Assisted Tomography
Issue number2
Publication statusPublished - Nov 9 2016


  • Aged
  • Aged, 80 and over
  • Brain Ischemia/complications
  • Carotid Arteries/diagnostic imaging
  • Carotid Stenosis/complications
  • Cohort Studies
  • Contrast Media
  • Female
  • Humans
  • Image Enhancement/methods
  • Magnetic Resonance Angiography/methods
  • Male
  • Meglumine/analogs & derivatives
  • Middle Aged
  • Myocardial Ischemia/complications
  • Organometallic Compounds
  • Plaque, Atherosclerotic/complications
  • Predictive Value of Tests
  • Prospective Studies


Dive into the research topics of 'Is Carotid Plaque Contrast Enhancement on MRI Predictive for Cerebral or Cardiovascular Events? A Prospective Cohort Study'. Together they form a unique fingerprint.

Cite this