OBJECTIVE: The aim of this study was to correlate carotid plaque contrast enhancement (CPCE) to onset of cerebral/cardiovascular events (CCVE) in patients with atherosclerotic carotid disease.
METHODS: The ethics committee approved this prospective study. Patients with carotid artery stenosis underwent magnetic resonance angiography before/after injection of 0.1 mmol/kg of gadobenate dimeglumine. Carotid plaque contrast enhancement was graded as follows: 0, no CPCE; 1, 1 single enhancement focus; 2, 2 or more foci.
RESULTS: Seventy-seven patients (71 ± 9 years) had a stenosis degree: 34 mild, 16 moderate, 27 severe at the right side, and 36, 15, and 25 at the left side. Carotid plaque contrast enhancement was 0 in 30 patients, 1 in 26, 2 in 11 at the right, and 37, 19, and 13 at the left. Forty-seven CCVE occurred after magnetic resonance imaging, correlated to both stenosis degree (P = 0.006) and CPCE (P = 0.032). Excluding surgery/stenting, the correlation held only for CPCE (P = 0.017). Of 49 patients showing CPCE, 5 (10%) reported CCVE; of 21 patients without CPCE, none reported CCVE (P = 0.129).
CONCLUSIONS: The absence of CPCE seems to be a negative predictor for CCVE.
- Aged, 80 and over
- Brain Ischemia/complications
- Carotid Arteries/diagnostic imaging
- Carotid Stenosis/complications
- Cohort Studies
- Contrast Media
- Image Enhancement/methods
- Magnetic Resonance Angiography/methods
- Meglumine/analogs & derivatives
- Middle Aged
- Myocardial Ischemia/complications
- Organometallic Compounds
- Plaque, Atherosclerotic/complications
- Predictive Value of Tests
- Prospective Studies