Is Carotid Plaque Contrast Enhancement on MRI Predictive for Cerebral or Cardiovascular Events?: A Prospective Cohort Study

Giacomo Davide Edoardo Papini; Giovanni Di Leo; Michele Bandirali; Biagio Cotticelli; Nicola Flor; Pietro Restivo; Giovanni Nano; Francesco Sardanelli

doi:10.1097/RCT.0000000000000506

Is Carotid Plaque Contrast Enhancement on MRI Predictive for Cerebral or Cardiovascular Events? A Prospective Cohort Study

Giacomo Davide Edoardo Papini, Giovanni Di Leo, Michele Bandirali, Biagio Cotticelli, Nicola Flor, Pietro Restivo, Giovanni Nano, Francesco Sardanelli

IRCCS Policlinico San Donato

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE: The aim of this study was to correlate carotid plaque contrast enhancement (CPCE) to onset of cerebral/cardiovascular events (CCVE) in patients with atherosclerotic carotid disease.

METHODS: The ethics committee approved this prospective study. Patients with carotid artery stenosis underwent magnetic resonance angiography before/after injection of 0.1 mmol/kg of gadobenate dimeglumine. Carotid plaque contrast enhancement was graded as follows: 0, no CPCE; 1, 1 single enhancement focus; 2, 2 or more foci.

RESULTS: Seventy-seven patients (71 ± 9 years) had a stenosis degree: 34 mild, 16 moderate, 27 severe at the right side, and 36, 15, and 25 at the left side. Carotid plaque contrast enhancement was 0 in 30 patients, 1 in 26, 2 in 11 at the right, and 37, 19, and 13 at the left. Forty-seven CCVE occurred after magnetic resonance imaging, correlated to both stenosis degree (P = 0.006) and CPCE (P = 0.032). Excluding surgery/stenting, the correlation held only for CPCE (P = 0.017). Of 49 patients showing CPCE, 5 (10%) reported CCVE; of 21 patients without CPCE, none reported CCVE (P = 0.129).

CONCLUSIONS: The absence of CPCE seems to be a negative predictor for CCVE.

Original language	English
Pages (from-to)	321-326
Number of pages	6
Journal	Journal of Computer Assisted Tomography
Volume	41
Issue number	2
DOIs	https://doi.org/10.1097/RCT.0000000000000506
Publication status	Published - Nov 9 2016

Keywords

Aged
Aged, 80 and over
Brain Ischemia/complications
Carotid Arteries/diagnostic imaging
Carotid Stenosis/complications
Cohort Studies
Contrast Media
Female
Humans
Image Enhancement/methods
Magnetic Resonance Angiography/methods
Male
Meglumine/analogs & derivatives
Middle Aged
Myocardial Ischemia/complications
Organometallic Compounds
Plaque, Atherosclerotic/complications
Predictive Value of Tests
Prospective Studies

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10.1097/RCT.0000000000000506

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@article{6ee5bd3b94fa457898e061e3e9948284,

title = "Is Carotid Plaque Contrast Enhancement on MRI Predictive for Cerebral or Cardiovascular Events?: A Prospective Cohort Study",

abstract = "OBJECTIVE: The aim of this study was to correlate carotid plaque contrast enhancement (CPCE) to onset of cerebral/cardiovascular events (CCVE) in patients with atherosclerotic carotid disease.METHODS: The ethics committee approved this prospective study. Patients with carotid artery stenosis underwent magnetic resonance angiography before/after injection of 0.1 mmol/kg of gadobenate dimeglumine. Carotid plaque contrast enhancement was graded as follows: 0, no CPCE; 1, 1 single enhancement focus; 2, 2 or more foci.RESULTS: Seventy-seven patients (71 ± 9 years) had a stenosis degree: 34 mild, 16 moderate, 27 severe at the right side, and 36, 15, and 25 at the left side. Carotid plaque contrast enhancement was 0 in 30 patients, 1 in 26, 2 in 11 at the right, and 37, 19, and 13 at the left. Forty-seven CCVE occurred after magnetic resonance imaging, correlated to both stenosis degree (P = 0.006) and CPCE (P = 0.032). Excluding surgery/stenting, the correlation held only for CPCE (P = 0.017). Of 49 patients showing CPCE, 5 (10%) reported CCVE; of 21 patients without CPCE, none reported CCVE (P = 0.129).CONCLUSIONS: The absence of CPCE seems to be a negative predictor for CCVE.",

keywords = "Aged, Aged, 80 and over, Brain Ischemia/complications, Carotid Arteries/diagnostic imaging, Carotid Stenosis/complications, Cohort Studies, Contrast Media, Female, Humans, Image Enhancement/methods, Magnetic Resonance Angiography/methods, Male, Meglumine/analogs & derivatives, Middle Aged, Myocardial Ischemia/complications, Organometallic Compounds, Plaque, Atherosclerotic/complications, Predictive Value of Tests, Prospective Studies",

author = "Papini, {Giacomo Davide Edoardo} and {Di Leo}, Giovanni and Michele Bandirali and Biagio Cotticelli and Nicola Flor and Pietro Restivo and Giovanni Nano and Francesco Sardanelli",

year = "2016",

month = nov,

day = "9",

doi = "10.1097/RCT.0000000000000506",

language = "English",

volume = "41",

pages = "321--326",

journal = "Journal of Computer Assisted Tomography",

issn = "0363-8715",

publisher = "Lippincott Williams and Wilkins",

number = "2",

}

TY - JOUR

T1 - Is Carotid Plaque Contrast Enhancement on MRI Predictive for Cerebral or Cardiovascular Events?

T2 - A Prospective Cohort Study

AU - Papini, Giacomo Davide Edoardo

AU - Di Leo, Giovanni

AU - Bandirali, Michele

AU - Cotticelli, Biagio

AU - Flor, Nicola

AU - Restivo, Pietro

AU - Nano, Giovanni

AU - Sardanelli, Francesco

PY - 2016/11/9

Y1 - 2016/11/9

N2 - OBJECTIVE: The aim of this study was to correlate carotid plaque contrast enhancement (CPCE) to onset of cerebral/cardiovascular events (CCVE) in patients with atherosclerotic carotid disease.METHODS: The ethics committee approved this prospective study. Patients with carotid artery stenosis underwent magnetic resonance angiography before/after injection of 0.1 mmol/kg of gadobenate dimeglumine. Carotid plaque contrast enhancement was graded as follows: 0, no CPCE; 1, 1 single enhancement focus; 2, 2 or more foci.RESULTS: Seventy-seven patients (71 ± 9 years) had a stenosis degree: 34 mild, 16 moderate, 27 severe at the right side, and 36, 15, and 25 at the left side. Carotid plaque contrast enhancement was 0 in 30 patients, 1 in 26, 2 in 11 at the right, and 37, 19, and 13 at the left. Forty-seven CCVE occurred after magnetic resonance imaging, correlated to both stenosis degree (P = 0.006) and CPCE (P = 0.032). Excluding surgery/stenting, the correlation held only for CPCE (P = 0.017). Of 49 patients showing CPCE, 5 (10%) reported CCVE; of 21 patients without CPCE, none reported CCVE (P = 0.129).CONCLUSIONS: The absence of CPCE seems to be a negative predictor for CCVE.

AB - OBJECTIVE: The aim of this study was to correlate carotid plaque contrast enhancement (CPCE) to onset of cerebral/cardiovascular events (CCVE) in patients with atherosclerotic carotid disease.METHODS: The ethics committee approved this prospective study. Patients with carotid artery stenosis underwent magnetic resonance angiography before/after injection of 0.1 mmol/kg of gadobenate dimeglumine. Carotid plaque contrast enhancement was graded as follows: 0, no CPCE; 1, 1 single enhancement focus; 2, 2 or more foci.RESULTS: Seventy-seven patients (71 ± 9 years) had a stenosis degree: 34 mild, 16 moderate, 27 severe at the right side, and 36, 15, and 25 at the left side. Carotid plaque contrast enhancement was 0 in 30 patients, 1 in 26, 2 in 11 at the right, and 37, 19, and 13 at the left. Forty-seven CCVE occurred after magnetic resonance imaging, correlated to both stenosis degree (P = 0.006) and CPCE (P = 0.032). Excluding surgery/stenting, the correlation held only for CPCE (P = 0.017). Of 49 patients showing CPCE, 5 (10%) reported CCVE; of 21 patients without CPCE, none reported CCVE (P = 0.129).CONCLUSIONS: The absence of CPCE seems to be a negative predictor for CCVE.

KW - Aged

KW - Aged, 80 and over

KW - Brain Ischemia/complications

KW - Carotid Arteries/diagnostic imaging

KW - Carotid Stenosis/complications

KW - Cohort Studies

KW - Contrast Media

KW - Female

KW - Humans

KW - Image Enhancement/methods

KW - Magnetic Resonance Angiography/methods

KW - Male

KW - Meglumine/analogs & derivatives

KW - Middle Aged

KW - Myocardial Ischemia/complications

KW - Organometallic Compounds

KW - Plaque, Atherosclerotic/complications

KW - Predictive Value of Tests

KW - Prospective Studies

U2 - 10.1097/RCT.0000000000000506

DO - 10.1097/RCT.0000000000000506

M3 - Article

C2 - 27824664

VL - 41

SP - 321

EP - 326

JO - Journal of Computer Assisted Tomography

JF - Journal of Computer Assisted Tomography

SN - 0363-8715

IS - 2

ER -

Is Carotid Plaque Contrast Enhancement on MRI Predictive for Cerebral or Cardiovascular Events? A Prospective Cohort Study

Abstract

Keywords

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