Is chronic fatigue the symptom of venous insufficiency associated with multiple sclerosis? A longitudinal pilot study

A. M. Malagoni, R. Galeotti, E. Menegatti, F. Manfredini, N. Basaglia, F. Salvi, P. Zamboni

Research output: Contribution to journalArticlepeer-review

Abstract

Aim. Chronic fatigue (CF) severely affects patients with multiple sclerosis (MS), but its pathogenesis remains elusive and the effectiveness of available treatments is modest. We aimed to evaluate the effect on CF of the balloon dilatation of stenosing lesions affecting the main extracranial veins configuring the chronic cerebrospinal venous insufficiency (CCSVI), a condition strongly associated with MS. Methods. Thirty-one MS consecutive patients (16 males, age 46.2±9.4 years) with associated CCSVI and CF underwent the endovascular procedure. Fatigue was assessed using the Fatigue Severity Scale (FSS) and Modified Fatigue Impact Scale (MFIS) at baseline (T0) and one (T1), six (T6) and twelve (T12) months after the procedure. In ambulatory patients (N.=28), mobility was evaluated using the 6-min walking test at T0 and T1. Results. FSS and MFIS scores significantly improved from preoperative values, and the positive trend was maintained at one year (FSS: T0=5.1±1.0 to T12=3.5±1.8, P

Original languageEnglish
Pages (from-to)176-182
Number of pages7
JournalInternational Angiology
Volume29
Issue number2
Publication statusPublished - Apr 2010

Keywords

  • Angioplasty, balloon
  • Cerebrovascular accidents
  • Fatigue
  • Multiple sclerosis
  • Venous insufficiency

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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