Is circulating D-dimer level a better prognostic indicator than CEA in resectable colorectal cancer? Our experience on 199 cases

Corrado Pedrazzani, Guido Cerullo, Daniele Marrelli, Eduardo Fernandes, Filippo Carlucci, Giovanni Corso, Francesca Bettarini, Alfonso De Stefano, Franco Roviello

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To evaluate the clinical impact of D-dimer (DD) as a tumor marker in patients with colorectal cancer (CRC). The prognostic value of preoperative DD measurement was assessed in relation to carcinoembryonic antigen (CEA) levels. Methods: DD and CEA levels were measured preoperatively in 199 patients who underwent resection for CRC and the results were analyzed statistically. Results: The preoperative mean (±SD) levels of DD and CEA were 347.5 (±940.1) ng/mL and 106.4 (±1099.2) ng/mL. The DD level was significantly correlated with the nature of surgery (emergency vs. elective; p=0.002), presence of residual tumor (R1-2 vs R0; p=0.037), and tumor diameter (p

Original languageEnglish
Pages (from-to)171-176
Number of pages6
JournalInternational Journal of Biological Markers
Volume25
Issue number3
Publication statusPublished - Jul 2010

Keywords

  • Carcinoembryonic antigen
  • Colorectal carcinoma
  • D-dimer
  • Prognosis

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cancer Research
  • Oncology
  • Pathology and Forensic Medicine

Fingerprint Dive into the research topics of 'Is circulating D-dimer level a better prognostic indicator than CEA in resectable colorectal cancer? Our experience on 199 cases'. Together they form a unique fingerprint.

Cite this