Is contrast enhancement needed for diagnostic prostate MRI?

Michele Scialpi, Valeria Rondoni, Maria Cristina Aisa, Eugenio Martorana, Alfredo D'Andrea, Corrado Maria Malaspina, Agostino Orlandi, Giorgio Galassi, Emanuele Orlandi, Pietro Scialpi, Michele Dragone, Diego Palladino, Annalisa Simeone, Michele Amenta, Giampaolo Bianchi

Research output: Contribution to journalReview articlepeer-review


Prostate Imaging Reporting and Data System version 2 (PI-RADS v2) provides clinical guidelines for multiparametric magnetic resonance imaging (mpMRI) [T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI)] of prostate. However, DCE-MRI seems to show a limited contribution in prostate cancer (PCa) detection and management. In our experience, DCE-MRI, did not show significant change in diagnostic performance in addition to DWI and T2WI [biparametric MRI (bpMRI)] which represent the predominant sequences to detect suspected lesions in peripheral and transitional zone (TZ). In this article we reviewed the role of DCE-MRI also indicating the potential contribute of bpMRI approach (T2WI and DWI) and lesion volume evaluation in the diagnosis and management of suspected PCa.

Original languageEnglish
Pages (from-to)499-509
Number of pages11
JournalTranslational Andrology and Urology
Issue number3
Publication statusPublished - Jun 1 2017


  • Biparametric magnetic resonance imaging (bpMRI)
  • Prostate cancer (PCa)
  • Prostate Imaging Reporting and Data System version 2 (PI-RADS v2)

ASJC Scopus subject areas

  • Reproductive Medicine
  • Urology


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