Is Cronkhite-Canada Syndrome necessarily a late-onset disease?

Piero Vernia, Adriana Marcheggiano, Vanessa Marinaro, Santo Morabito, Isabella Guzzo, Alessandro Pierucci

Research output: Contribution to journalArticlepeer-review


Cronkhite-Canada Syndrome is a non-inherited, non-congenital disease characterized by juvenile hamartomatous gastrointestinal polyps with a typically late onset. In the case described herein the disease was diagnosed in a 17-year-old male with type I diabetes and thalassaemia minor, in coincidence with severe symptomatic intestinal candidiasis. Following the disappearance of the mycosis and correction of the protein and electrolyte imbalance, the ectodermal abnormalities returned to normal and the patient remained asymptomatic during a 7-year follow-up period, despite proteinuria resulting from membranous glomerulopathy. The concept that Cronkhite-Canada Syndrome is a late-onset disease should probably be reconsidered as it may remain asymptomatic, and thus not diagnosed, for a long a time.

Original languageEnglish
Pages (from-to)1139-1141
Number of pages3
JournalEuropean Journal of Gastroenterology and Hepatology
Issue number10
Publication statusPublished - Oct 2005


  • Cronkhite-Canada Syndrome
  • Juvenile polyposis
  • Polyposis

ASJC Scopus subject areas

  • Gastroenterology


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