Is cyclosporine in renal-transplant recipients more effective when given twice a day than in a single daily dose?

Antonio Tarantino, Patrizia Passerini, Mariarosaria Campise, Erminio Bonizzoni, Fulvia Ceccarini, Giuseppe Montagnino, Adriana Aroldi, Claudio Ponticelli

Research output: Contribution to journalArticle

Abstract

Background. It is still unknown whether it is better to administer cyclosporine (CsA) once or twice a day to renal-transplant patients. Methods. Fifty-four patients were randomized to receive CsA once a day (OD group, 28 patients) or twice a day (BD group, 26 patients). Clinical parameters and pharmacokinetic studies were regularly monitored over the first year. Results. Two patients lost their grafts because of renal vascular thrombosis. A patient in the BD group died. The other 51 patients were alive with graft functioning after a minimum follow-up of 1 year. Five patients per group had reversible acute rejection. There was a not significant trend toward a lower mean serum creatinine in OD than in BD (1.38±0.38 and 1.7±0.80 mg/dL at 1 year posttransplant, respectively). In 47 patients, 319 pharmacokinetic studies were performed. We measured the area under the concentration-time curve during the first 4 hours (AUC0-4) and CsA blood levels at 0, 2, and 4 hours after dosing. C0 was significantly lower in OD than in BD (P= 0.0011), whereas C2 (P

Original languageEnglish
Pages (from-to)675-680
Number of pages6
JournalTransplantation
Volume78
Issue number5
DOIs
Publication statusPublished - Sep 15 2004

ASJC Scopus subject areas

  • Transplantation
  • Immunology

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    Tarantino, A., Passerini, P., Campise, M., Bonizzoni, E., Ceccarini, F., Montagnino, G., Aroldi, A., & Ponticelli, C. (2004). Is cyclosporine in renal-transplant recipients more effective when given twice a day than in a single daily dose? Transplantation, 78(5), 675-680. https://doi.org/10.1097/01.TP.0000129806.69681.15