Is expression of p120ctn in oral squamous cell carcinomas a prognostic factor?

Lorenzo Lo Muzio; Giuseppe Pannone; Andrea Santarelli; Fabrizio Bambini; Marco Mascitti; Corrado Rubini; Nunzio F. Testa; Mario Dioguardi; Stefania Leuci; Antonio Bascones; Albert B. Reynolds; Maria Addolorata Mariggiò

doi:10.1016/j.oooo.2013.03.006

Is expression of p120ctn in oral squamous cell carcinomas a prognostic factor?

Lorenzo Lo Muzio, Giuseppe Pannone, Andrea Santarelli, Fabrizio Bambini, Marco Mascitti, Corrado Rubini, Nunzio F. Testa, Mario Dioguardi, Stefania Leuci, Antonio Bascones, Albert B. Reynolds, Maria Addolorata Mariggiò

Istituto Nazionale di Riposo e Cura per Anziani V.E. II

Research output: Contribution to journal › Article › peer-review

Abstract

Objectives: p120ctn is a component of the catenin family. To date, there have only been two studies examining expression levels of p120ctn in oral squamous cell carcinoma (OSCC). Materials and methods: Paraffined specimens of 113 OSCCs and 12 of normal mucosa were examined by immunohistochemistry. Frozen samples of 20 OSCCs and 5 of normal mucosa were examined by Western blot (WB). Results were correlated with clinicopathological parameters. Five cell lines were examined by immunofluorescence, immunocytochemistry, and WB to show immunoreactivity and cellular localization of p120ctn. Results: Altered p120ctn expression was observed in 109/113 cases of OSCC. Heterogenous cytoplasmic/nuclear expression was associated with loss of membranous distribution (88/113 cases). Complete loss of expression was noted in 21/113 cases. Increased cytoplasmic expression was evident in all positive cases, without significant correlation among p120ctn staining/pattern and grading/stage. Reduction/absence of p120ctn expression was related to poor prognosis (P <.05). Conclusion: p120ctn delocalization/loss of expression could be an independent prognostic marker in OSCC.

Original language	English
Pages (from-to)	789-798
Number of pages	10
Journal	Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Volume	115
Issue number	6
DOIs	https://doi.org/10.1016/j.oooo.2013.03.006
Publication status	Published - Jun 2013

ASJC Scopus subject areas

Surgery
Oral Surgery
Pathology and Forensic Medicine
Radiology Nuclear Medicine and imaging
Dentistry (miscellaneous)

Access to Document

10.1016/j.oooo.2013.03.006

Cite this

Lo Muzio, L., Pannone, G., Santarelli, A., Bambini, F., Mascitti, M., Rubini, C., Testa, N. F., Dioguardi, M., Leuci, S., Bascones, A., Reynolds, A. B., & Mariggiò, M. A. (2013). Is expression of p120ctn in oral squamous cell carcinomas a prognostic factor? Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 115(6), 789-798. https://doi.org/10.1016/j.oooo.2013.03.006

Lo Muzio, L, Pannone, G, Santarelli, A, Bambini, F, Mascitti, M, Rubini, C, Testa, NF, Dioguardi, M, Leuci, S, Bascones, A, Reynolds, AB & Mariggiò, MA 2013, 'Is expression of p120ctn in oral squamous cell carcinomas a prognostic factor?', Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, vol. 115, no. 6, pp. 789-798. https://doi.org/10.1016/j.oooo.2013.03.006

@article{0027930e061144c18aa96aedb722fad1,

title = "Is expression of p120ctn in oral squamous cell carcinomas a prognostic factor?",

abstract = "Objectives: p120ctn is a component of the catenin family. To date, there have only been two studies examining expression levels of p120ctn in oral squamous cell carcinoma (OSCC). Materials and methods: Paraffined specimens of 113 OSCCs and 12 of normal mucosa were examined by immunohistochemistry. Frozen samples of 20 OSCCs and 5 of normal mucosa were examined by Western blot (WB). Results were correlated with clinicopathological parameters. Five cell lines were examined by immunofluorescence, immunocytochemistry, and WB to show immunoreactivity and cellular localization of p120ctn. Results: Altered p120ctn expression was observed in 109/113 cases of OSCC. Heterogenous cytoplasmic/nuclear expression was associated with loss of membranous distribution (88/113 cases). Complete loss of expression was noted in 21/113 cases. Increased cytoplasmic expression was evident in all positive cases, without significant correlation among p120ctn staining/pattern and grading/stage. Reduction/absence of p120ctn expression was related to poor prognosis (P <.05). Conclusion: p120ctn delocalization/loss of expression could be an independent prognostic marker in OSCC.",

author = "{Lo Muzio}, Lorenzo and Giuseppe Pannone and Andrea Santarelli and Fabrizio Bambini and Marco Mascitti and Corrado Rubini and Testa, {Nunzio F.} and Mario Dioguardi and Stefania Leuci and Antonio Bascones and Reynolds, {Albert B.} and Mariggi{\`o}, {Maria Addolorata}",

year = "2013",

month = jun,

doi = "10.1016/j.oooo.2013.03.006",

language = "English",

volume = "115",

pages = "789--798",

journal = "Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology",

issn = "2212-4403",