Is fixed severe pulmonary hypertension still a contraindication to heart transplant in the modern era of mechanical circulatory support? A review

Garatti Andrea, Bruschi Giuseppe, Colombo Tiziano, Frigerio Maria, Vitali Ettore

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Pulmonary vascular hypertension (PVH) is a common complication of severe, long-lasting chronic heart failure. It is nowadays well recognized that PVH, nonresponsive to pharmacological approaches, is a risk factor for early and late mortality after heart transplant. Recent evidences in literature highlighted that in these patients chronic unloading with left ventricular assist device resulted in significant reduction of pulmonary vascular resistance, thus ultimately leading them to successful heart transplant. We described the case history of a 47-year-old man with ischemic cardiomyopathy who underwent uncomplicated Berlin Heart Incor implant for severe chronic heart failure and fixed PVH. Chronic unloading determined a rapid and dramatic improvement of PVH, and the patient underwent successful heart transplant after 5 months of mechanical support.

Original languageEnglish
Pages (from-to)1059-1062
Number of pages4
JournalJournal of Cardiovascular Medicine
Volume9
Issue number10
DOIs
Publication statusPublished - Oct 2008

Fingerprint

Pulmonary Hypertension
Blood Vessels
Transplants
Heart Failure
Heart-Assist Devices
Berlin
Cardiomyopathies
Vascular Resistance
Pharmacology
Mortality

Keywords

  • Heart transplantation
  • Left ventricular assist device
  • Pulmonary hypertension

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Is fixed severe pulmonary hypertension still a contraindication to heart transplant in the modern era of mechanical circulatory support? A review. / Andrea, Garatti; Giuseppe, Bruschi; Tiziano, Colombo; Maria, Frigerio; Ettore, Vitali.

In: Journal of Cardiovascular Medicine, Vol. 9, No. 10, 10.2008, p. 1059-1062.

Research output: Contribution to journalArticle

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