Abstract
The primary pathogenic trigger in coeliac disease (CD) is still unknown. We present the hypothesis that in CD the enterocytes could metabolize gliadin through an immunogenic pathway instead of a tolerogenic one. The result of this abnormal presentation of gliadin to the immune system would be the activation of lamina propria T cells, followed by the onset of enteropathy.
Original language | English |
---|---|
Pages (from-to) | 119-122 |
Number of pages | 4 |
Journal | QJM |
Volume | 92 |
Issue number | 2 |
Publication status | Published - Feb 1999 |
ASJC Scopus subject areas
- Medicine(all)