Is gliadin mispresented to the immune system in coeliac disease? A hypothesis

F. Biagi; K. P. Zimmer; P. D. Thomas; H. J. Ellis; P. J. Ciclitira

Is gliadin mispresented to the immune system in coeliac disease? A hypothesis

F. Biagi, K. P. Zimmer, P. D. Thomas, H. J. Ellis, P. J. Ciclitira

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

The primary pathogenic trigger in coeliac disease (CD) is still unknown. We present the hypothesis that in CD the enterocytes could metabolize gliadin through an immunogenic pathway instead of a tolerogenic one. The result of this abnormal presentation of gliadin to the immune system would be the activation of lamina propria T cells, followed by the onset of enteropathy.

Original language	English
Pages (from-to)	119-122
Number of pages	4
Journal	QJM
Volume	92
Issue number	2
Publication status	Published - Feb 1999

ASJC Scopus subject areas

Medicine(all)

Cite this

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title = "Is gliadin mispresented to the immune system in coeliac disease? A hypothesis",

abstract = "The primary pathogenic trigger in coeliac disease (CD) is still unknown. We present the hypothesis that in CD the enterocytes could metabolize gliadin through an immunogenic pathway instead of a tolerogenic one. The result of this abnormal presentation of gliadin to the immune system would be the activation of lamina propria T cells, followed by the onset of enteropathy.",

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AU - Thomas, P. D.

AU - Ellis, H. J.

AU - Ciclitira, P. J.

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AB - The primary pathogenic trigger in coeliac disease (CD) is still unknown. We present the hypothesis that in CD the enterocytes could metabolize gliadin through an immunogenic pathway instead of a tolerogenic one. The result of this abnormal presentation of gliadin to the immune system would be the activation of lamina propria T cells, followed by the onset of enteropathy.

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Is gliadin mispresented to the immune system in coeliac disease? A hypothesis

Abstract

ASJC Scopus subject areas

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