Abstract
The primary pathogenic trigger in coeliac disease (CD) is still unknown. We present the hypothesis that in CD the enterocytes could metabolize gliadin through an immunogenic pathway instead of a tolerogenic one. The result of this abnormal presentation of gliadin to the immune system would be the activation of lamina propria T cells, followed by the onset of enteropathy.
| Original language | English |
|---|---|
| Pages (from-to) | 119-122 |
| Number of pages | 4 |
| Journal | QJM |
| Volume | 92 |
| Issue number | 2 |
| Publication status | Published - Feb 1999 |
ASJC Scopus subject areas
- Medicine(all)
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Biagi, F., Zimmer, K. P., Thomas, P. D., Ellis, H. J., & Ciclitira, P. J. (1999). Is gliadin mispresented to the immune system in coeliac disease? A hypothesis. QJM, 92(2), 119-122.