Is gliadin mispresented to the immune system in coeliac disease? A hypothesis

F. Biagi, K. P. Zimmer, P. D. Thomas, H. J. Ellis, P. J. Ciclitira

Research output: Contribution to journalArticle

Abstract

The primary pathogenic trigger in coeliac disease (CD) is still unknown. We present the hypothesis that in CD the enterocytes could metabolize gliadin through an immunogenic pathway instead of a tolerogenic one. The result of this abnormal presentation of gliadin to the immune system would be the activation of lamina propria T cells, followed by the onset of enteropathy.

Original languageEnglish
Pages (from-to)119-122
Number of pages4
JournalQJM
Volume92
Issue number2
Publication statusPublished - Feb 1999

ASJC Scopus subject areas

  • Medicine(all)

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    Biagi, F., Zimmer, K. P., Thomas, P. D., Ellis, H. J., & Ciclitira, P. J. (1999). Is gliadin mispresented to the immune system in coeliac disease? A hypothesis. QJM, 92(2), 119-122.