Is heart rate variability a reliable method to assess autonomic modulation in left ventricular dysfunction and heart failure? Assessment of autonomic modulation with heart rate variability

Simonetta Scalvini, Maurizio Volterrani, Emanuela Zanelli, Marco Pagani, Giorgio Mazzuero, Andrew J. Coats, Amerigo Giordano

Research output: Contribution to journalArticle

Abstract

Autonomic dysfunction seems to be involved in the progression and prognosis of congestive heart failure. Measurement of heart rate variability (HRV) provides a noninvasive method to obtain reliable and reproducible information on autonomic modulation of heart rate, but there is a difficulty in using HRV as a quantitative estimate of autonomic dysfunction in heart failure. This study was aimed at testing the hypothesis that abnormal modulation of heart rate assessed by power spectrum analysis may be present also in asymptomatic patients with left ventricular dysfunction and progress in patients with overt symptoms of congestive heart failure. HRV was measured in three groups of subjects: Group 1: 30 patients with chronic heart failure; Group 2: 21 patients with asymptomatic left ventricular dysfunction; and Group 3: 25 healthy volunteers as control group. HRV was evaluated by autoregressive spectral analysis with 600-beat ECG samples, while subjects were quietly recumbent (BSl), in conditions of controlled breathing (15 acts/min) (RSC) and passive orthostatism after tilting (80°) (TLT). Patients in group I showed a reduction in the standard deviation of the R-R intervals (SDRR) (p

Original languageEnglish
Pages (from-to)9-17
Number of pages9
JournalInternational Journal of Cardiology
Volume67
Issue number1
DOIs
Publication statusPublished - Nov 30 1998

Keywords

  • Chronic heart failure
  • Heart rate variability
  • Left ventricular dysfunction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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