Is Helicobacter pylori a cause of atrial fibrillation?

Peter Andrew, Annibale Sandro Montenero

Research output: Contribution to journalArticlepeer-review


Inflammation has been implicated in the pathogenesis of cardiovascular diseases. C-reactive protein, a sensitive marker of systemic inflammation, has recently been reported to be significantly higher in patients with atrial fibrillation (AF) compared with a control group with no history of atrial arrhythmia. Elevated C-reactive protein levels in patients with AF reflects an underlying inflammatory process. Histological anomalies in the atria of patients with AF have also been observed. These anomalies may have an inflammatory basis, although it is not known if any structural changes within the atria are a cause or a consequence of the arrhythmia. Ongoing chronic infection(s) has been suggested as a possible cause of the inflammatory process demonstrated in patients with AF. Helicobacter pylori, a Gram-negative bacterium more commonly known for infecting the gastric mucosa and causing peptic ulcers, is a noncardiac factor that has been controversially reported to be associated with cardiovascular diseases. This article gives a brief overview of AF and specifically explores the recent evidence that suggests that Helicobacter pylori infection causes AF.

Original languageEnglish
Pages (from-to)429-439
Number of pages11
JournalFuture Cardiology
Issue number4
Publication statusPublished - Jul 2006


  • Amoxicillin
  • Arrhythmia
  • Atrial fibrillation
  • C-reactive protein
  • Helicobacter pylori
  • Infection
  • Inflammation

ASJC Scopus subject areas

  • Molecular Medicine
  • Cardiology and Cardiovascular Medicine


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