Is Hepatic Resection for Large or Multifocal Intrahepatic Cholangiocarcinoma Justified? Results from a Multi-Institutional Collaboration

Gaya Spolverato, Yuhree Kim, Sorin Alexandrescu, Irinel Popescu, Hugo P. Marques, Luca Aldrighetti, T. Clark Gamblin, John Miura, Shishir K. Maithel, Malcolm H. Squires, Carlo Pulitano, Charbel Sandroussi, Gilles Mentha, Todd W. Bauer, Timothy Newhook, Feng Shen, George A. Poultsides, J. Wallis Marsh, Timothy M. Pawlik

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27 Citations (Scopus)

Abstract

Background: The role of surgical resection for patients with large or multifocal intrahepatic cholangiocarcinoma (ICC) remains unclear. This study evaluated the long-term outcome of patients who underwent hepatic resection for large (≥7 cm) or multifocal (≥2) ICC. Methods: Between 1990 and 2013, 557 patients who underwent liver resection for ICC were identified from a multi-institutional database. Clinicopathologic characteristics, operative details, and long-term survival data were evaluated. Results: Of the 557 patients, 215 (38.6 %) had a small, solitary ICC (group A) and 342 (61.4 %) had a large or multifocal ICC (group B). The patients in group B underwent an extended hepatectomy more frequently (16.9 vs. 30.4 %; P  0.05). The group A patients had better rates for 5-year overall survival (OS) (30.5 vs. 18.7 %; P 

Original languageEnglish
Pages (from-to)2218-2225
Number of pages8
JournalAnnals of Surgical Oncology
Volume22
Issue number7
DOIs
Publication statusPublished - Oct 30 2014

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Cholangiocarcinoma
Liver
Survival
Hepatectomy
Databases

ASJC Scopus subject areas

  • Surgery
  • Oncology

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Is Hepatic Resection for Large or Multifocal Intrahepatic Cholangiocarcinoma Justified? Results from a Multi-Institutional Collaboration. / Spolverato, Gaya; Kim, Yuhree; Alexandrescu, Sorin; Popescu, Irinel; Marques, Hugo P.; Aldrighetti, Luca; Clark Gamblin, T.; Miura, John; Maithel, Shishir K.; Squires, Malcolm H.; Pulitano, Carlo; Sandroussi, Charbel; Mentha, Gilles; Bauer, Todd W.; Newhook, Timothy; Shen, Feng; Poultsides, George A.; Wallis Marsh, J.; Pawlik, Timothy M.

In: Annals of Surgical Oncology, Vol. 22, No. 7, 30.10.2014, p. 2218-2225.

Research output: Contribution to journal › Article

Spolverato, G, Kim, Y, Alexandrescu, S, Popescu, I, Marques, HP, Aldrighetti, L, Clark Gamblin, T, Miura, J, Maithel, SK, Squires, MH, Pulitano, C, Sandroussi, C, Mentha, G, Bauer, TW, Newhook, T, Shen, F, Poultsides, GA, Wallis Marsh, J & Pawlik, TM 2014, 'Is Hepatic Resection for Large or Multifocal Intrahepatic Cholangiocarcinoma Justified? Results from a Multi-Institutional Collaboration', Annals of Surgical Oncology, vol. 22, no. 7, pp. 2218-2225. https://doi.org/10.1245/s10434-014-4223-3
Spolverato G, Kim Y, Alexandrescu S, Popescu I, Marques HP, Aldrighetti L et al. Is Hepatic Resection for Large or Multifocal Intrahepatic Cholangiocarcinoma Justified? Results from a Multi-Institutional Collaboration. Annals of Surgical Oncology. 2014 Oct 30;22(7):2218-2225. https://doi.org/10.1245/s10434-014-4223-3
Spolverato, Gaya ; Kim, Yuhree ; Alexandrescu, Sorin ; Popescu, Irinel ; Marques, Hugo P. ; Aldrighetti, Luca ; Clark Gamblin, T. ; Miura, John ; Maithel, Shishir K. ; Squires, Malcolm H. ; Pulitano, Carlo ; Sandroussi, Charbel ; Mentha, Gilles ; Bauer, Todd W. ; Newhook, Timothy ; Shen, Feng ; Poultsides, George A. ; Wallis Marsh, J. ; Pawlik, Timothy M. / Is Hepatic Resection for Large or Multifocal Intrahepatic Cholangiocarcinoma Justified? Results from a Multi-Institutional Collaboration. In: Annals of Surgical Oncology. 2014 ; Vol. 22, No. 7. pp. 2218-2225.
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abstract = "Background: The role of surgical resection for patients with large or multifocal intrahepatic cholangiocarcinoma (ICC) remains unclear. This study evaluated the long-term outcome of patients who underwent hepatic resection for large (≥7 cm) or multifocal (≥2) ICC. Methods: Between 1990 and 2013, 557 patients who underwent liver resection for ICC were identified from a multi-institutional database. Clinicopathologic characteristics, operative details, and long-term survival data were evaluated. Results: Of the 557 patients, 215 (38.6 {\%}) had a small, solitary ICC (group A) and 342 (61.4 {\%}) had a large or multifocal ICC (group B). The patients in group B underwent an extended hepatectomy more frequently (16.9 vs. 30.4 {\%}; P  0.05). The group A patients had better rates for 5-year overall survival (OS) (30.5 vs. 18.7 {\%}; P ",
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AU - Kim, Yuhree

AU - Alexandrescu, Sorin

AU - Popescu, Irinel

AU - Marques, Hugo P.

AU - Aldrighetti, Luca

AU - Clark Gamblin, T.

AU - Miura, John

AU - Maithel, Shishir K.

AU - Squires, Malcolm H.

AU - Pulitano, Carlo

AU - Sandroussi, Charbel

AU - Mentha, Gilles

AU - Bauer, Todd W.

AU - Newhook, Timothy

AU - Shen, Feng

AU - Poultsides, George A.

AU - Wallis Marsh, J.

AU - Pawlik, Timothy M.

PY - 2014/10/30

Y1 - 2014/10/30

N2 - Background: The role of surgical resection for patients with large or multifocal intrahepatic cholangiocarcinoma (ICC) remains unclear. This study evaluated the long-term outcome of patients who underwent hepatic resection for large (≥7 cm) or multifocal (≥2) ICC. Methods: Between 1990 and 2013, 557 patients who underwent liver resection for ICC were identified from a multi-institutional database. Clinicopathologic characteristics, operative details, and long-term survival data were evaluated. Results: Of the 557 patients, 215 (38.6 %) had a small, solitary ICC (group A) and 342 (61.4 %) had a large or multifocal ICC (group B). The patients in group B underwent an extended hepatectomy more frequently (16.9 vs. 30.4 %; P  0.05). The group A patients had better rates for 5-year overall survival (OS) (30.5 vs. 18.7 %; P 

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