Is Hepatic Resection for Large or Multifocal Intrahepatic Cholangiocarcinoma Justified? Results from a Multi-Institutional Collaboration

Gaya Spolverato; Yuhree Kim; Sorin Alexandrescu; Irinel Popescu; Hugo P. Marques; Luca Aldrighetti; T. Clark Gamblin; John Miura; Shishir K. Maithel; Malcolm H. Squires; Carlo Pulitano; Charbel Sandroussi; Gilles Mentha; Todd W. Bauer; Timothy Newhook; Feng Shen; George A. Poultsides; J. Wallis Marsh; Timothy M. Pawlik

doi:10.1245/s10434-014-4223-3

Is Hepatic Resection for Large or Multifocal Intrahepatic Cholangiocarcinoma Justified? Results from a Multi-Institutional Collaboration

Gaya Spolverato, Yuhree Kim, Sorin Alexandrescu, Irinel Popescu, Hugo P. Marques, Luca Aldrighetti, T. Clark Gamblin, John Miura, Shishir K. Maithel, Malcolm H. Squires, Carlo Pulitano, Charbel Sandroussi, Gilles Mentha, Todd W. Bauer, Timothy Newhook, Feng Shen, George A. Poultsides, J. Wallis Marsh, Timothy M. Pawlik

IRCCS Ospedale San Raffaele

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Abstract

Background: The role of surgical resection for patients with large or multifocal intrahepatic cholangiocarcinoma (ICC) remains unclear. This study evaluated the long-term outcome of patients who underwent hepatic resection for large (≥7 cm) or multifocal (≥2) ICC. Methods: Between 1990 and 2013, 557 patients who underwent liver resection for ICC were identified from a multi-institutional database. Clinicopathologic characteristics, operative details, and long-term survival data were evaluated. Results: Of the 557 patients, 215 (38.6 %) had a small, solitary ICC (group A) and 342 (61.4 %) had a large or multifocal ICC (group B). The patients in group B underwent an extended hepatectomy more frequently (16.9 vs. 30.4 %; P 0.05). The group A patients had better rates for 5-year overall survival (OS) (30.5 vs. 18.7 %; P

Original language	English
Pages (from-to)	2218-2225
Number of pages	8
Journal	Annals of Surgical Oncology
Volume	22
Issue number	7
DOIs	https://doi.org/10.1245/s10434-014-4223-3
Publication status	Published - Oct 30 2014

ASJC Scopus subject areas

Surgery
Oncology

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10.1245/s10434-014-4223-3

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Spolverato, G., Kim, Y., Alexandrescu, S., Popescu, I., Marques, H. P., Aldrighetti, L., Clark Gamblin, T., Miura, J., Maithel, S. K., Squires, M. H., Pulitano, C., Sandroussi, C., Mentha, G., Bauer, T. W., Newhook, T., Shen, F., Poultsides, G. A., Wallis Marsh, J., & Pawlik, T. M. (2014). Is Hepatic Resection for Large or Multifocal Intrahepatic Cholangiocarcinoma Justified? Results from a Multi-Institutional Collaboration. Annals of Surgical Oncology, 22(7), 2218-2225. https://doi.org/10.1245/s10434-014-4223-3

Spolverato, G, Kim, Y, Alexandrescu, S, Popescu, I, Marques, HP, Aldrighetti, L, Clark Gamblin, T, Miura, J, Maithel, SK, Squires, MH, Pulitano, C, Sandroussi, C, Mentha, G, Bauer, TW, Newhook, T, Shen, F, Poultsides, GA, Wallis Marsh, J & Pawlik, TM 2014, 'Is Hepatic Resection for Large or Multifocal Intrahepatic Cholangiocarcinoma Justified? Results from a Multi-Institutional Collaboration', Annals of Surgical Oncology, vol. 22, no. 7, pp. 2218-2225. https://doi.org/10.1245/s10434-014-4223-3

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title = "Is Hepatic Resection for Large or Multifocal Intrahepatic Cholangiocarcinoma Justified? Results from a Multi-Institutional Collaboration",

abstract = "Background: The role of surgical resection for patients with large or multifocal intrahepatic cholangiocarcinoma (ICC) remains unclear. This study evaluated the long-term outcome of patients who underwent hepatic resection for large (≥7 cm) or multifocal (≥2) ICC. Methods: Between 1990 and 2013, 557 patients who underwent liver resection for ICC were identified from a multi-institutional database. Clinicopathologic characteristics, operative details, and long-term survival data were evaluated. Results: Of the 557 patients, 215 (38.6 %) had a small, solitary ICC (group A) and 342 (61.4 %) had a large or multifocal ICC (group B). The patients in group B underwent an extended hepatectomy more frequently (16.9 vs. 30.4 %; P 0.05). The group A patients had better rates for 5-year overall survival (OS) (30.5 vs. 18.7 %; P ",

author = "Gaya Spolverato and Yuhree Kim and Sorin Alexandrescu and Irinel Popescu and Marques, {Hugo P.} and Luca Aldrighetti and {Clark Gamblin}, T. and John Miura and Maithel, {Shishir K.} and Squires, {Malcolm H.} and Carlo Pulitano and Charbel Sandroussi and Gilles Mentha and Bauer, {Todd W.} and Timothy Newhook and Feng Shen and Poultsides, {George A.} and {Wallis Marsh}, J. and Pawlik, {Timothy M.}",

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doi = "10.1245/s10434-014-4223-3",

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T1 - Is Hepatic Resection for Large or Multifocal Intrahepatic Cholangiocarcinoma Justified? Results from a Multi-Institutional Collaboration

AU - Spolverato, Gaya

AU - Kim, Yuhree

AU - Alexandrescu, Sorin

AU - Popescu, Irinel

AU - Marques, Hugo P.

AU - Aldrighetti, Luca

AU - Clark Gamblin, T.

AU - Miura, John

AU - Maithel, Shishir K.

AU - Squires, Malcolm H.

AU - Pulitano, Carlo

AU - Sandroussi, Charbel

AU - Mentha, Gilles

AU - Bauer, Todd W.

AU - Newhook, Timothy

AU - Shen, Feng

AU - Poultsides, George A.

AU - Wallis Marsh, J.

AU - Pawlik, Timothy M.

PY - 2014/10/30

Y1 - 2014/10/30

N2 - Background: The role of surgical resection for patients with large or multifocal intrahepatic cholangiocarcinoma (ICC) remains unclear. This study evaluated the long-term outcome of patients who underwent hepatic resection for large (≥7 cm) or multifocal (≥2) ICC. Methods: Between 1990 and 2013, 557 patients who underwent liver resection for ICC were identified from a multi-institutional database. Clinicopathologic characteristics, operative details, and long-term survival data were evaluated. Results: Of the 557 patients, 215 (38.6 %) had a small, solitary ICC (group A) and 342 (61.4 %) had a large or multifocal ICC (group B). The patients in group B underwent an extended hepatectomy more frequently (16.9 vs. 30.4 %; P 0.05). The group A patients had better rates for 5-year overall survival (OS) (30.5 vs. 18.7 %; P

AB - Background: The role of surgical resection for patients with large or multifocal intrahepatic cholangiocarcinoma (ICC) remains unclear. This study evaluated the long-term outcome of patients who underwent hepatic resection for large (≥7 cm) or multifocal (≥2) ICC. Methods: Between 1990 and 2013, 557 patients who underwent liver resection for ICC were identified from a multi-institutional database. Clinicopathologic characteristics, operative details, and long-term survival data were evaluated. Results: Of the 557 patients, 215 (38.6 %) had a small, solitary ICC (group A) and 342 (61.4 %) had a large or multifocal ICC (group B). The patients in group B underwent an extended hepatectomy more frequently (16.9 vs. 30.4 %; P 0.05). The group A patients had better rates for 5-year overall survival (OS) (30.5 vs. 18.7 %; P

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Is Hepatic Resection for Large or Multifocal Intrahepatic Cholangiocarcinoma Justified? Results from a Multi-Institutional Collaboration

Abstract

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