TY - JOUR
T1 - Is high oral dose L-arginine intake effective in leukoaraiosis? Preliminary data, study protocol and expert's opinion
AU - Calabró, Rocco Salvatore
AU - Gervasi, Giuseppe
AU - Baglieri, Annalisa
AU - Furnari, Anna
AU - Marino, Silvia
AU - Bramanti, Placido
PY - 2013
Y1 - 2013
N2 - Background: Leukoraraiosis is worldwide considered as a part of the normal aging process, although it is strongly associated with dementia and other disabilities. The pathogenesis of leukoaraiosis still has not been thoroughly acknowledged, even though chronic ischemia with consequent arteriolosclerosis probably due to endothelial dysfunction has been suggested. Treatment focuses on prevention of lesion formation and progression by aggressive control of risk factors, which should begin at an early age and continue on regular basis. Aim of our protocol is to evaluate the effect of long-term oral administration of high-dose L-arginine (6 g/day at least for 24 months) on white matter lesions and neurological and cognitive functions. Materials and Methods: Patients affected by mild to moderate leukoaraiosis will be enrolled in the study. After a complete neurovascular assessment (i.e. accurate blood test examinations, Echocardiography, Doppler ultrasound of the neck and peripheral arteries), they will undergo MRI, specific neuropsychological tests and gait analysis. Patients will be evaluated at baseline, at 6, 12, 18 and 24 month-follow up. Statistical Analysis will be performed using the software R. A significant level of P
AB - Background: Leukoraraiosis is worldwide considered as a part of the normal aging process, although it is strongly associated with dementia and other disabilities. The pathogenesis of leukoaraiosis still has not been thoroughly acknowledged, even though chronic ischemia with consequent arteriolosclerosis probably due to endothelial dysfunction has been suggested. Treatment focuses on prevention of lesion formation and progression by aggressive control of risk factors, which should begin at an early age and continue on regular basis. Aim of our protocol is to evaluate the effect of long-term oral administration of high-dose L-arginine (6 g/day at least for 24 months) on white matter lesions and neurological and cognitive functions. Materials and Methods: Patients affected by mild to moderate leukoaraiosis will be enrolled in the study. After a complete neurovascular assessment (i.e. accurate blood test examinations, Echocardiography, Doppler ultrasound of the neck and peripheral arteries), they will undergo MRI, specific neuropsychological tests and gait analysis. Patients will be evaluated at baseline, at 6, 12, 18 and 24 month-follow up. Statistical Analysis will be performed using the software R. A significant level of P
KW - Cognitive decline
KW - Gait imbalance
KW - L-arginine
KW - Leukoaraiosis
KW - Magnetic resonance
KW - Neuropsychological assessment
UR - http://www.scopus.com/inward/record.url?scp=84882785203&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84882785203&partnerID=8YFLogxK
U2 - 10.2174/1874609811306020005
DO - 10.2174/1874609811306020005
M3 - Article
AN - SCOPUS:84882785203
VL - 6
SP - 170
EP - 177
JO - Current Aging Science
JF - Current Aging Science
SN - 1874-6128
IS - 2
ER -