Is high oral dose L-arginine intake effective in leukoaraiosis? Preliminary data, study protocol and expert's opinion

Rocco Salvatore Calabró, Giuseppe Gervasi, Annalisa Baglieri, Anna Furnari, Silvia Marino, Placido Bramanti

Research output: Contribution to journalArticle


Background: Leukoraraiosis is worldwide considered as a part of the normal aging process, although it is strongly associated with dementia and other disabilities. The pathogenesis of leukoaraiosis still has not been thoroughly acknowledged, even though chronic ischemia with consequent arteriolosclerosis probably due to endothelial dysfunction has been suggested. Treatment focuses on prevention of lesion formation and progression by aggressive control of risk factors, which should begin at an early age and continue on regular basis. Aim of our protocol is to evaluate the effect of long-term oral administration of high-dose L-arginine (6 g/day at least for 24 months) on white matter lesions and neurological and cognitive functions. Materials and Methods: Patients affected by mild to moderate leukoaraiosis will be enrolled in the study. After a complete neurovascular assessment (i.e. accurate blood test examinations, Echocardiography, Doppler ultrasound of the neck and peripheral arteries), they will undergo MRI, specific neuropsychological tests and gait analysis. Patients will be evaluated at baseline, at 6, 12, 18 and 24 month-follow up. Statistical Analysis will be performed using the software R. A significant level of P

Original languageEnglish
Pages (from-to)170-177
Number of pages8
JournalCurrent Aging Science
Issue number2
Publication statusPublished - 2013



  • Cognitive decline
  • Gait imbalance
  • L-arginine
  • Leukoaraiosis
  • Magnetic resonance
  • Neuropsychological assessment

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology

Cite this