E possibile predire l'effetto antiaritmico dei betabloccanti in base al riconoscimento di differenti relazioni tra battiti prematuri ventricolari ed il precedente ciclo cardiaco?

Translated title of the contribution: Is it possible to predict the anti-arrhythmic effect of beta blockers based on various relations between premature ventricular beat and the preceding cardiac cycle?

M. Pitzalis, F. Massari, P. Totaro, F. Mastropasqua, P. Rizzon

Research output: Contribution to journalArticle

Abstract

The aim of our study was to correlate betablocker effects on premature ventricular beats (PVBs) with different patterns between PVB frequency and cardiac cycle. The computer program we used correlates each PVB to the preceding cycle length in a 24-hour electrocardiogram recording. The arrhythmic patterns obtained were defined as tachycardia-dependent, indifferent and bradycardia-dependent. We selected 51 patients (39 males, 12 females, mean age 52 years) with different cardiac diseases, all in sinus rhythm, with > 25 PVBs/h, characterized by PVB stability and reproducible pattern in 2 Holter monitoring recorded at a 3-5 day interval. A tachycardia-dependent pattern (TDP) was demonstrated in 20 patients; 22 patients showed an indifferent pattern (IP) and 9 a bradycardia-dependent pattern (BDP). A third Holter monitoring was performed 4-5 days after nadolol administration (80 mg/day). Nadolol caused a 87.7% PVB suppression in TDP patients (p <0.001), a 34.8% PVB reduction in IP patients (p <0.01) and a 36.3% increase in BDP patients (NS). The different effect of nadolol on these groups was highly significant (chi 2 30.9; p <0.0001). These results indicate that pattern definitions is useful in identifying PVB subsets which are likely to be improved, or not, by betablockers.

Translated title of the contributionIs it possible to predict the anti-arrhythmic effect of beta blockers based on various relations between premature ventricular beat and the preceding cardiac cycle?
Original languageItalian
Pages (from-to)853-857
Number of pages5
JournalCardiologia
Volume37
Issue number12
Publication statusPublished - Dec 1992

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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