Abstract
Hairy cell leukemia (HCL) patients could have an excellent prognosis with adequate treatment. Treatments are not generally curative but are extremely effective in inducing long-lasting clinical remissions. An observational retrospective study was conducted on a single-center registry of 144 patients with a median follow-up of 11.5 years, focusing on long-lasting continuous first complete remissions (CR) wondering if patients can be cured only with front-line approach. CR for more than 5 years after first-line therapy were found in 22.2 % cases. The median duration of response was 9.8 years, while for relapsed patients, the first response had a median duration of 2.4 years. Three different subsets of long-lasting first CR were identified: 15 patients are between 5 and 10 years with a median duration of CR of 6.5 years; 7 patients are between 10 and 15 years with a median duration of CR of 12.3 years; and 10 patients present a follow-up superior to 15 years with a median duration of CR of 20.0 years. There is a need for continuous study in this field to better define the optimal therapeutic regimen and, in particular, the biological issues since at least 20-25 % of HCL patients can be cured with only one treatment.
| Original language | English |
|---|---|
| Pages (from-to) | 1565-1569 |
| Number of pages | 5 |
| Journal | Annals of Hematology |
| Volume | 93 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 2014 |
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Keywords
- Continuous complete response
- First-line therapy
- Hairy cell leukemia
- New drugs
- Purine analogs
ASJC Scopus subject areas
- Hematology
Cite this
Is it really possible to cure hairy cell leukemia patients only with frontline therapy? / Zinzani, Pier Luigi; Stefoni, Vittorio; Broccoli, Alessandro; Pellegrini, Cinzia; Gandolfi, Letizia; Casadei, Beatrice; Maglie, Roberto; Pileri, Stefano; Argnani, Lisa.
In: Annals of Hematology, Vol. 93, No. 9, 2014, p. 1565-1569.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Is it really possible to cure hairy cell leukemia patients only with frontline therapy?
AU - Zinzani, Pier Luigi
AU - Stefoni, Vittorio
AU - Broccoli, Alessandro
AU - Pellegrini, Cinzia
AU - Gandolfi, Letizia
AU - Casadei, Beatrice
AU - Maglie, Roberto
AU - Pileri, Stefano
AU - Argnani, Lisa
PY - 2014
Y1 - 2014
N2 - Hairy cell leukemia (HCL) patients could have an excellent prognosis with adequate treatment. Treatments are not generally curative but are extremely effective in inducing long-lasting clinical remissions. An observational retrospective study was conducted on a single-center registry of 144 patients with a median follow-up of 11.5 years, focusing on long-lasting continuous first complete remissions (CR) wondering if patients can be cured only with front-line approach. CR for more than 5 years after first-line therapy were found in 22.2 % cases. The median duration of response was 9.8 years, while for relapsed patients, the first response had a median duration of 2.4 years. Three different subsets of long-lasting first CR were identified: 15 patients are between 5 and 10 years with a median duration of CR of 6.5 years; 7 patients are between 10 and 15 years with a median duration of CR of 12.3 years; and 10 patients present a follow-up superior to 15 years with a median duration of CR of 20.0 years. There is a need for continuous study in this field to better define the optimal therapeutic regimen and, in particular, the biological issues since at least 20-25 % of HCL patients can be cured with only one treatment.
AB - Hairy cell leukemia (HCL) patients could have an excellent prognosis with adequate treatment. Treatments are not generally curative but are extremely effective in inducing long-lasting clinical remissions. An observational retrospective study was conducted on a single-center registry of 144 patients with a median follow-up of 11.5 years, focusing on long-lasting continuous first complete remissions (CR) wondering if patients can be cured only with front-line approach. CR for more than 5 years after first-line therapy were found in 22.2 % cases. The median duration of response was 9.8 years, while for relapsed patients, the first response had a median duration of 2.4 years. Three different subsets of long-lasting first CR were identified: 15 patients are between 5 and 10 years with a median duration of CR of 6.5 years; 7 patients are between 10 and 15 years with a median duration of CR of 12.3 years; and 10 patients present a follow-up superior to 15 years with a median duration of CR of 20.0 years. There is a need for continuous study in this field to better define the optimal therapeutic regimen and, in particular, the biological issues since at least 20-25 % of HCL patients can be cured with only one treatment.
KW - Continuous complete response
KW - First-line therapy
KW - Hairy cell leukemia
KW - New drugs
KW - Purine analogs
UR - http://www.scopus.com/inward/record.url?scp=84905565640&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84905565640&partnerID=8YFLogxK
U2 - 10.1007/s00277-014-2081-5
DO - 10.1007/s00277-014-2081-5
M3 - Article
C2 - 24752417
AN - SCOPUS:84905565640
VL - 93
SP - 1565
EP - 1569
JO - Annals of Hematology
JF - Annals of Hematology
SN - 0939-5555
IS - 9
ER -