Is It Time to Introduce PET/CT in Colon Cancer Guidelines?

Anna Margherita Maffione, Domenico Rubello, Paola Caroli, Patrick M Colletti, Federica Matteucci

Research output: Contribution to journalArticlepeer-review


International colon cancer guidelines suggest F-FDG PET/CT in a few circumstances: (1) at disease presentation in case of suspected or proven metastatic synchronous adenocarcinoma; (2) in the workup of recurrent colon cancer with metachronous metastases documented by CT, MRI, or biopsy and in case of serial CEA elevation with negative colonoscopy and negative CT; and (3) in case of contraindication to iodine- and gadolinium-based contrast agents. However, review of the literature has shown that PET/CT can also be used in other scenarios with significant levels of diagnostic advantage. This review aims to emphasize differences between guidelines and scientific literature for the use of PET/CT in colon cancer.

Original languageEnglish
Pages (from-to)525-530
Number of pages6
JournalClinical Nuclear Medicine
Issue number7
Publication statusPublished - Jul 2020


  • Adenocarcinoma/diagnostic imaging
  • Aged
  • Biopsy
  • Colonic Neoplasms/diagnostic imaging
  • Contrast Media
  • Female
  • Fluorodeoxyglucose F18
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Neoplasm Metastasis
  • Positron Emission Tomography Computed Tomography
  • Practice Guidelines as Topic


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