Is it time to revise antiretrovirals dosing? A pharmacokinetic viewpoint

Dario Cattaneo, Sara Baldelli, Simone Castoldi, Nitin Charbe, Valeria Cozzi, Serena Fucile, Emilio Clementi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We document our experience with therapeutic drug monitoring (TDM) of antiretroviral agents (1807 determinations) carried out as day-by-day clinical practice for the optimization of drug dosing in HIV-infected patients. A significant proportion of patients had lopinavir, atazanavir and nevirapine trough concentrations exceeding the upper therapeutic threshold. Further studies are needed to identify good candidates/drugs for TDM, eventually allowing the selection of patients who may benefit from TDM-driven adjustments in antiretrovirals dosage.

Original languageEnglish
Pages (from-to)2477-2480
Number of pages4
JournalAIDS (London, England)
Volume28
Issue number16
DOIs
Publication statusPublished - 2014

Fingerprint

Drug Monitoring
Pharmacokinetics
Lopinavir
Anti-Retroviral Agents
Nevirapine
Pharmaceutical Preparations
Patient Selection
HIV
Therapeutics

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases
  • Medicine(all)

Cite this

Cattaneo, D., Baldelli, S., Castoldi, S., Charbe, N., Cozzi, V., Fucile, S., & Clementi, E. (2014). Is it time to revise antiretrovirals dosing? A pharmacokinetic viewpoint. AIDS (London, England), 28(16), 2477-2480. https://doi.org/10.1097/QAD.0000000000000440

Is it time to revise antiretrovirals dosing? A pharmacokinetic viewpoint. / Cattaneo, Dario; Baldelli, Sara; Castoldi, Simone; Charbe, Nitin; Cozzi, Valeria; Fucile, Serena; Clementi, Emilio.

In: AIDS (London, England), Vol. 28, No. 16, 2014, p. 2477-2480.

Research output: Contribution to journalArticle

Cattaneo, D, Baldelli, S, Castoldi, S, Charbe, N, Cozzi, V, Fucile, S & Clementi, E 2014, 'Is it time to revise antiretrovirals dosing? A pharmacokinetic viewpoint', AIDS (London, England), vol. 28, no. 16, pp. 2477-2480. https://doi.org/10.1097/QAD.0000000000000440
Cattaneo D, Baldelli S, Castoldi S, Charbe N, Cozzi V, Fucile S et al. Is it time to revise antiretrovirals dosing? A pharmacokinetic viewpoint. AIDS (London, England). 2014;28(16):2477-2480. https://doi.org/10.1097/QAD.0000000000000440
Cattaneo, Dario ; Baldelli, Sara ; Castoldi, Simone ; Charbe, Nitin ; Cozzi, Valeria ; Fucile, Serena ; Clementi, Emilio. / Is it time to revise antiretrovirals dosing? A pharmacokinetic viewpoint. In: AIDS (London, England). 2014 ; Vol. 28, No. 16. pp. 2477-2480.
@article{64ea25b60a79459e82d06a25161e3f2e,
title = "Is it time to revise antiretrovirals dosing? A pharmacokinetic viewpoint",
abstract = "We document our experience with therapeutic drug monitoring (TDM) of antiretroviral agents (1807 determinations) carried out as day-by-day clinical practice for the optimization of drug dosing in HIV-infected patients. A significant proportion of patients had lopinavir, atazanavir and nevirapine trough concentrations exceeding the upper therapeutic threshold. Further studies are needed to identify good candidates/drugs for TDM, eventually allowing the selection of patients who may benefit from TDM-driven adjustments in antiretrovirals dosage.",
author = "Dario Cattaneo and Sara Baldelli and Simone Castoldi and Nitin Charbe and Valeria Cozzi and Serena Fucile and Emilio Clementi",
year = "2014",
doi = "10.1097/QAD.0000000000000440",
language = "English",
volume = "28",
pages = "2477--2480",
journal = "AIDS",
issn = "0269-9370",
publisher = "NLM (Medline)",
number = "16",

}

TY - JOUR

T1 - Is it time to revise antiretrovirals dosing? A pharmacokinetic viewpoint

AU - Cattaneo, Dario

AU - Baldelli, Sara

AU - Castoldi, Simone

AU - Charbe, Nitin

AU - Cozzi, Valeria

AU - Fucile, Serena

AU - Clementi, Emilio

PY - 2014

Y1 - 2014

N2 - We document our experience with therapeutic drug monitoring (TDM) of antiretroviral agents (1807 determinations) carried out as day-by-day clinical practice for the optimization of drug dosing in HIV-infected patients. A significant proportion of patients had lopinavir, atazanavir and nevirapine trough concentrations exceeding the upper therapeutic threshold. Further studies are needed to identify good candidates/drugs for TDM, eventually allowing the selection of patients who may benefit from TDM-driven adjustments in antiretrovirals dosage.

AB - We document our experience with therapeutic drug monitoring (TDM) of antiretroviral agents (1807 determinations) carried out as day-by-day clinical practice for the optimization of drug dosing in HIV-infected patients. A significant proportion of patients had lopinavir, atazanavir and nevirapine trough concentrations exceeding the upper therapeutic threshold. Further studies are needed to identify good candidates/drugs for TDM, eventually allowing the selection of patients who may benefit from TDM-driven adjustments in antiretrovirals dosage.

UR - http://www.scopus.com/inward/record.url?scp=84916208892&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84916208892&partnerID=8YFLogxK

U2 - 10.1097/QAD.0000000000000440

DO - 10.1097/QAD.0000000000000440

M3 - Article

VL - 28

SP - 2477

EP - 2480

JO - AIDS

JF - AIDS

SN - 0269-9370

IS - 16

ER -