Is kidney ischemia the central mechanism in parallel activation of the renin and sympathetic system?

Laima Siddiqi, Jaap A. Joles, Guido Grassi, Peter J. Blankestijn

Research output: Contribution to journalArticlepeer-review

Abstract

In chronic kidney disease simultaneous activation of the renin-angiotensin and sympathetic systems occurs. Kidney ischemia seems to play a key role in the pathogenesis. This review firstly summarizes experimental and clinical evidence in chronic kidney disease supporting this idea and addresses the possibility that this mechanism is also relevant in some other disease conditions.

Original languageEnglish
Pages (from-to)1341-1349
Number of pages9
JournalJournal of Hypertension
Volume27
Issue number7
DOIs
Publication statusPublished - Jul 2009

Keywords

  • Angiotensin converting enzyme inhibition
  • Angiotensin II antagonism
  • Angiotensin II receptor blockade
  • Chronic kidney disease
  • Kidney ischemia
  • Renin angiotensin aldosterone system
  • Sympathetic nerve activity

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

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