Is magnetic resonance imaging useful in early evaluation of women on neoadjuvant chemotherapy for locally advanced cervical cancer?

P. Sala, P. Marchiolè, G. Cittadini, M. Valenzano Menada, M. Moioli, S. Mammoliti, S. Costantini

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: To evaluate the accuracy of magnetic resonance imaging (MRI) in staging cervical tumors after neoadjuvant chemotherapy (NACT). Methods: 26 women, affected by locally advanced cervical cancer and triaged for surgery after NACT, were submitted to three cycles of neoadjuvant chemotherapy. All patients were submitted to MRI before and after NACT. We evaluated the MRI sensitivity and specificity in staging cervical tumors after chemotherapy, relating MRI findings after NACT with the pathological findings as the gold standard. Results: In our series, MRI sensitivity was 58.8% and specificity was 66.7%. Conclusions: In our study MRI accuracy after NACT was lower than that of MRI used to stage patients with early cervical cancer scheduled for primary surgery, reported by the literature. MRI false negative cases are the major problem because of the delay in application of an effective therapy in non responders to NACT.

Original languageEnglish
Pages (from-to)31-36
Number of pages6
JournalEuropean Journal of Gynaecological Oncology
Volume33
Issue number1
Publication statusPublished - 2012

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Uterine Cervical Neoplasms
Magnetic Resonance Imaging
Drug Therapy
Neoplasm Staging
Sensitivity and Specificity

Keywords

  • Early response evaluation
  • Locally advanced cervical cancer (LACC)
  • Magnetic resonance imaging (MRI)
  • Neoadjuvant chemotherapy (NACT)

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology

Cite this

Is magnetic resonance imaging useful in early evaluation of women on neoadjuvant chemotherapy for locally advanced cervical cancer? / Sala, P.; Marchiolè, P.; Cittadini, G.; Valenzano Menada, M.; Moioli, M.; Mammoliti, S.; Costantini, S.

In: European Journal of Gynaecological Oncology, Vol. 33, No. 1, 2012, p. 31-36.

Research output: Contribution to journalArticle

Sala, P. ; Marchiolè, P. ; Cittadini, G. ; Valenzano Menada, M. ; Moioli, M. ; Mammoliti, S. ; Costantini, S. / Is magnetic resonance imaging useful in early evaluation of women on neoadjuvant chemotherapy for locally advanced cervical cancer?. In: European Journal of Gynaecological Oncology. 2012 ; Vol. 33, No. 1. pp. 31-36.
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