Is minimally invasive spine surgery also minimally pro-inflammatory? Muscular markers, inflammatory parameters and cytokines to quantify the operative invasiveness assessment in spine fusion

Giovanni Lombardi, D. Grasso, P. Berjano, G. Banfi, C. Lamartina

Research output: Contribution to journalArticle

Abstract

Over the last decades, minimally invasive surgery (MIS) techniques entered in the surgical routine due to their major advantage in reducing the unnecessary exposure of tissue and, thus, the trauma. Even in the context of orthopedics and spine surgery these practices have been widely developed and applied. Besides the clinical outcome of the patients, few studies have quantitatively assessed the traumatic and inflammatory effects of a specific surgical technique. Indeed, currently, a universally accepted biological outcome measure, such as a panel of biochemical markers, to define the success of MIS approach is still lacking. We reviewed the literature to collect the published data regarding the quantitative analysis of trauma induced by either conventional or minimally invasive surgery with the aim of highlighting evidence useful to guide future studies. Previous publications show some evidence in support of the hypothesis that MIS approaches are less traumatic, and possibly less pro-inflammatory, than conventional ones. Creatin kinase (as a marker of muscular damage) and C-reactive protein (as a marker of systemic inflammation) seem to reproducibly follow different trends in minimally invasive surgery compared to conventional procedures. Moreover, cytokines, such as interleukin (IL)-6 and IL-10 are also promising markers in this context.

Original languageEnglish
Pages (from-to)237-249
Number of pages13
JournalEuropean Journal of Inflammation
Volume12
Issue number2
Publication statusPublished - 2014

Fingerprint

Minimally Invasive Surgical Procedures
Spine
Cytokines
Wounds and Injuries
Interleukin-10
C-Reactive Protein
Orthopedics
Interleukin-6
Phosphotransferases
Biomarkers
Outcome Assessment (Health Care)
Inflammation

Keywords

  • Cytokines
  • Inflammation
  • Minimally invasive surgery
  • Muscle markers
  • Spine fusion

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

@article{9a7b747a2a9f4a1ca1b415a3e6dcd8a0,
title = "Is minimally invasive spine surgery also minimally pro-inflammatory? Muscular markers, inflammatory parameters and cytokines to quantify the operative invasiveness assessment in spine fusion",
abstract = "Over the last decades, minimally invasive surgery (MIS) techniques entered in the surgical routine due to their major advantage in reducing the unnecessary exposure of tissue and, thus, the trauma. Even in the context of orthopedics and spine surgery these practices have been widely developed and applied. Besides the clinical outcome of the patients, few studies have quantitatively assessed the traumatic and inflammatory effects of a specific surgical technique. Indeed, currently, a universally accepted biological outcome measure, such as a panel of biochemical markers, to define the success of MIS approach is still lacking. We reviewed the literature to collect the published data regarding the quantitative analysis of trauma induced by either conventional or minimally invasive surgery with the aim of highlighting evidence useful to guide future studies. Previous publications show some evidence in support of the hypothesis that MIS approaches are less traumatic, and possibly less pro-inflammatory, than conventional ones. Creatin kinase (as a marker of muscular damage) and C-reactive protein (as a marker of systemic inflammation) seem to reproducibly follow different trends in minimally invasive surgery compared to conventional procedures. Moreover, cytokines, such as interleukin (IL)-6 and IL-10 are also promising markers in this context.",
keywords = "Cytokines, Inflammation, Minimally invasive surgery, Muscle markers, Spine fusion",
author = "Giovanni Lombardi and D. Grasso and P. Berjano and G. Banfi and C. Lamartina",
year = "2014",
language = "English",
volume = "12",
pages = "237--249",
journal = "European Journal of Inflammation",
issn = "1721-727X",
publisher = "Biolife",
number = "2",

}

TY - JOUR

T1 - Is minimally invasive spine surgery also minimally pro-inflammatory? Muscular markers, inflammatory parameters and cytokines to quantify the operative invasiveness assessment in spine fusion

AU - Lombardi, Giovanni

AU - Grasso, D.

AU - Berjano, P.

AU - Banfi, G.

AU - Lamartina, C.

PY - 2014

Y1 - 2014

N2 - Over the last decades, minimally invasive surgery (MIS) techniques entered in the surgical routine due to their major advantage in reducing the unnecessary exposure of tissue and, thus, the trauma. Even in the context of orthopedics and spine surgery these practices have been widely developed and applied. Besides the clinical outcome of the patients, few studies have quantitatively assessed the traumatic and inflammatory effects of a specific surgical technique. Indeed, currently, a universally accepted biological outcome measure, such as a panel of biochemical markers, to define the success of MIS approach is still lacking. We reviewed the literature to collect the published data regarding the quantitative analysis of trauma induced by either conventional or minimally invasive surgery with the aim of highlighting evidence useful to guide future studies. Previous publications show some evidence in support of the hypothesis that MIS approaches are less traumatic, and possibly less pro-inflammatory, than conventional ones. Creatin kinase (as a marker of muscular damage) and C-reactive protein (as a marker of systemic inflammation) seem to reproducibly follow different trends in minimally invasive surgery compared to conventional procedures. Moreover, cytokines, such as interleukin (IL)-6 and IL-10 are also promising markers in this context.

AB - Over the last decades, minimally invasive surgery (MIS) techniques entered in the surgical routine due to their major advantage in reducing the unnecessary exposure of tissue and, thus, the trauma. Even in the context of orthopedics and spine surgery these practices have been widely developed and applied. Besides the clinical outcome of the patients, few studies have quantitatively assessed the traumatic and inflammatory effects of a specific surgical technique. Indeed, currently, a universally accepted biological outcome measure, such as a panel of biochemical markers, to define the success of MIS approach is still lacking. We reviewed the literature to collect the published data regarding the quantitative analysis of trauma induced by either conventional or minimally invasive surgery with the aim of highlighting evidence useful to guide future studies. Previous publications show some evidence in support of the hypothesis that MIS approaches are less traumatic, and possibly less pro-inflammatory, than conventional ones. Creatin kinase (as a marker of muscular damage) and C-reactive protein (as a marker of systemic inflammation) seem to reproducibly follow different trends in minimally invasive surgery compared to conventional procedures. Moreover, cytokines, such as interleukin (IL)-6 and IL-10 are also promising markers in this context.

KW - Cytokines

KW - Inflammation

KW - Minimally invasive surgery

KW - Muscle markers

KW - Spine fusion

UR - http://www.scopus.com/inward/record.url?scp=84905868240&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84905868240&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:84905868240

VL - 12

SP - 237

EP - 249

JO - European Journal of Inflammation

JF - European Journal of Inflammation

SN - 1721-727X

IS - 2

ER -