Abstract
The occurrence of occult cervical metastases due to squamous-cell carcinoma of the hard palate and maxillary alveolar ridge has not been studied systematically. We have observed that many patients return with a delayed cervical metastasis following resection of a primary cancer at these sites. Some of these patients have died as a result of a regional or distant metastasis, despite control of the primary cancer. The literature contains few recommendations to guide the treatment of maxillary squamous-cell carcinoma; prospective studies are difficult due to the rarity of such tumours. The aim of this study is to define the incidence of cervical metastasis and to investigate whether elective neck dissection is justified. We present a retrospective multicentre study of 65 patients with squamous-cell carcinomas of the maxillary alveolar ridge and hard palate and review of the existing literature. The overall incidence of cervical metastases was 21%. We evaluated the significance of primary-site tumours as indicator of regional disease. The maxillary squamous-cell carcinoma cases in our multicentre study and in the literature review exhibited aggressive regional metastatic behaviour, comparable with that of carcinomas of the tongue, mouth floor, and mandibular gingiva. Based on our findings, we recommend selective neck dissection in clinically negative necks as a primary management strategy for patients with maxillary squamous-cell carcinomas involving the palate, maxillary gingiva, or maxillary alveolus.
| Original language | English |
|---|---|
| Pages (from-to) | 97-101 |
| Number of pages | 5 |
| Journal | Oral Oncology |
| Volume | 48 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2012 |
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Keywords
- Cervical metastasis
- Hard palate
- Neck dissection
- Squamous-cell carcinoma
ASJC Scopus subject areas
- Oncology
- Oral Surgery
- Cancer Research
Cite this
Is neck dissection needed in squamous-cell carcinoma of the maxillary gingiva, alveolus, and hard palate? A multicentre Italian study of 65 cases and literature review. / Beltramini, Giada A.; Massarelli, Olindo; Demarchi, Marco; Copelli, Chiara; Cassoni, Andrea; Valentini, Valentino; Tullio, Antonio; Giann, Aldo B.; Sesenna, Enrico; Baj, Alessandro.
In: Oral Oncology, Vol. 48, No. 2, 02.2012, p. 97-101.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Is neck dissection needed in squamous-cell carcinoma of the maxillary gingiva, alveolus, and hard palate? A multicentre Italian study of 65 cases and literature review
AU - Beltramini, Giada A.
AU - Massarelli, Olindo
AU - Demarchi, Marco
AU - Copelli, Chiara
AU - Cassoni, Andrea
AU - Valentini, Valentino
AU - Tullio, Antonio
AU - Giann, Aldo B.
AU - Sesenna, Enrico
AU - Baj, Alessandro
PY - 2012/2
Y1 - 2012/2
N2 - The occurrence of occult cervical metastases due to squamous-cell carcinoma of the hard palate and maxillary alveolar ridge has not been studied systematically. We have observed that many patients return with a delayed cervical metastasis following resection of a primary cancer at these sites. Some of these patients have died as a result of a regional or distant metastasis, despite control of the primary cancer. The literature contains few recommendations to guide the treatment of maxillary squamous-cell carcinoma; prospective studies are difficult due to the rarity of such tumours. The aim of this study is to define the incidence of cervical metastasis and to investigate whether elective neck dissection is justified. We present a retrospective multicentre study of 65 patients with squamous-cell carcinomas of the maxillary alveolar ridge and hard palate and review of the existing literature. The overall incidence of cervical metastases was 21%. We evaluated the significance of primary-site tumours as indicator of regional disease. The maxillary squamous-cell carcinoma cases in our multicentre study and in the literature review exhibited aggressive regional metastatic behaviour, comparable with that of carcinomas of the tongue, mouth floor, and mandibular gingiva. Based on our findings, we recommend selective neck dissection in clinically negative necks as a primary management strategy for patients with maxillary squamous-cell carcinomas involving the palate, maxillary gingiva, or maxillary alveolus.
AB - The occurrence of occult cervical metastases due to squamous-cell carcinoma of the hard palate and maxillary alveolar ridge has not been studied systematically. We have observed that many patients return with a delayed cervical metastasis following resection of a primary cancer at these sites. Some of these patients have died as a result of a regional or distant metastasis, despite control of the primary cancer. The literature contains few recommendations to guide the treatment of maxillary squamous-cell carcinoma; prospective studies are difficult due to the rarity of such tumours. The aim of this study is to define the incidence of cervical metastasis and to investigate whether elective neck dissection is justified. We present a retrospective multicentre study of 65 patients with squamous-cell carcinomas of the maxillary alveolar ridge and hard palate and review of the existing literature. The overall incidence of cervical metastases was 21%. We evaluated the significance of primary-site tumours as indicator of regional disease. The maxillary squamous-cell carcinoma cases in our multicentre study and in the literature review exhibited aggressive regional metastatic behaviour, comparable with that of carcinomas of the tongue, mouth floor, and mandibular gingiva. Based on our findings, we recommend selective neck dissection in clinically negative necks as a primary management strategy for patients with maxillary squamous-cell carcinomas involving the palate, maxillary gingiva, or maxillary alveolus.
KW - Cervical metastasis
KW - Hard palate
KW - Neck dissection
KW - Squamous-cell carcinoma
UR - http://www.scopus.com/inward/record.url?scp=84856342740&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84856342740&partnerID=8YFLogxK
U2 - 10.1016/j.oraloncology.2011.08.012
DO - 10.1016/j.oraloncology.2011.08.012
M3 - Article
C2 - 21993155
AN - SCOPUS:84856342740
VL - 48
SP - 97
EP - 101
JO - Oral Oncology
JF - Oral Oncology
SN - 1368-8375
IS - 2
ER -