TY - JOUR
T1 - Is night-time hypertension worse than daytime hypertension? A study on cardiac damage in a general population
T2 - the PAMELA study
AU - Cuspidi, Cesare
AU - Facchetti, Rita
AU - Bombelli, Michele
AU - Sala, Carla
AU - Tadic, Marijana
AU - Grassi, Guido
AU - Mancia, Giuseppe
PY - 2017/3
Y1 - 2017/3
N2 - AIM:: Scanty information is available about the association of isolated daytime hypertension (IDH) and isolated night-time hypertension (INH) with subclinical cardiac damage in the general population. We examined this issue in patients enrolled in the Pressioni Arteriose Monitorate E Loro Associazioni study. METHODS:: The analysis included 2021 participants with valid ambulatory blood pressure (BP) monitoring at baseline evaluation. IDH and INH were defined according to current guidelines. Subclinical organ damage was assessed by validated electrocardiographic and echocardiographic criteria. RESULTS:: A total of 1258 patients (62.3%) had daytime/night-time normotension, 376 (18.6%) daytime/night-time hypertension, 231 (11.4%) INH and 156 (7.7%) IDH, respectively. Participants with hypertension, compared with their normotensive counterparts were older, included a higher fraction of men, had higher BMI, LDL cholesterol, triglyceride and glucose levels and exhibited a greater subclinical cardiac involvement. Furthermore, INH and IDH patients showed a similar degree of cardiac damage (i.e. left ventricular mass index: 89?±?18 vs 90?±?20?g/m), intermediate between normotensive (82?±?19?g/m) and day–night hypertensive patients (99?±?24?g/m). CONCLUSION:: The present study shows that IDH and INH exert similar detrimental effects on cardiac structure. In a practical perspective, appropriate antihypertensive chrono-therapeutic approaches in these opposite ambulatory hypertensive subtypes may have important implications in cardiovascular prevention.
AB - AIM:: Scanty information is available about the association of isolated daytime hypertension (IDH) and isolated night-time hypertension (INH) with subclinical cardiac damage in the general population. We examined this issue in patients enrolled in the Pressioni Arteriose Monitorate E Loro Associazioni study. METHODS:: The analysis included 2021 participants with valid ambulatory blood pressure (BP) monitoring at baseline evaluation. IDH and INH were defined according to current guidelines. Subclinical organ damage was assessed by validated electrocardiographic and echocardiographic criteria. RESULTS:: A total of 1258 patients (62.3%) had daytime/night-time normotension, 376 (18.6%) daytime/night-time hypertension, 231 (11.4%) INH and 156 (7.7%) IDH, respectively. Participants with hypertension, compared with their normotensive counterparts were older, included a higher fraction of men, had higher BMI, LDL cholesterol, triglyceride and glucose levels and exhibited a greater subclinical cardiac involvement. Furthermore, INH and IDH patients showed a similar degree of cardiac damage (i.e. left ventricular mass index: 89?±?18 vs 90?±?20?g/m), intermediate between normotensive (82?±?19?g/m) and day–night hypertensive patients (99?±?24?g/m). CONCLUSION:: The present study shows that IDH and INH exert similar detrimental effects on cardiac structure. In a practical perspective, appropriate antihypertensive chrono-therapeutic approaches in these opposite ambulatory hypertensive subtypes may have important implications in cardiovascular prevention.
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U2 - 10.1097/HJH.0000000000001193
DO - 10.1097/HJH.0000000000001193
M3 - Article
AN - SCOPUS:85002188860
VL - 3
SP - 506
EP - 512
JO - Journal of Hypertension
JF - Journal of Hypertension
SN - 0263-6352
ER -