Is non-alcoholic fatty liver disease less frequent among women with prader-willi syndrome?

Giorgio Bedogni, Graziano Grugni, Valerio Nobili, Fiorenza Agosti, Antonella Saezza, Alessandro Sartorio

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective: Patients with Prader-Willi syndrome (PWS) have been hypothesized to be at lower risk of non-alcoholic fatty liver disease (NAFLD) because of higher insulin sensitivity. However, PWS patients have a peculiar body composition, i.e. higher fat mass and lower fat-free mass, which may confound such associations. We evaluated whether NAFLD is less frequent in PWS than in non-PWS women matched on percent body fat (PBF). Methods: PBF was measured by dual-energy X-ray absorptiometry. Liver fat was assessed by ultrasonography. Insulin sensitivity and beta-cell function were evaluated by oral glucose tolerance testing. Coarsened exact matching (CEM) was used to match PWS and non-PWS women on PBF. General and generalized linear models taking CEM into account were used to perform comparisons between PWS and non-PWS women. Results: 20 women with PWS were matched to 27 women without PWS on the basis of PBF (mean 53 vs. 54%, p = 0.6). Insulin sensitivity and beta-cell function were similar in the two groups. However, the prevalence of NAFLD was 25% in PWS versus 59% in non-PWS women (p = 0.04). Conclusion: NAFLD is less frequent in PWS than in non-PWS women but this finding is not associated with higher insulin sensitivity.

Original languageEnglish
Pages (from-to)71-76
Number of pages6
JournalObesity Facts
Volume7
Issue number1
DOIs
Publication statusPublished - 2014

Fingerprint

Prader-Willi Syndrome
Disease
Insulin Resistance
Adipose Tissue
tolerance testing
Fats
linear model
Non-alcoholic Fatty Liver Disease
Photon Absorptiometry
Glucose Tolerance Test
Body Composition
energy
Linear Models
Ultrasonography

Keywords

  • Body composition
  • Dual energy X-ray absorptiometry
  • Insulin resistance
  • Obesity
  • Prader-Willi syndrome

ASJC Scopus subject areas

  • Physiology (medical)
  • Health(social science)

Cite this

Is non-alcoholic fatty liver disease less frequent among women with prader-willi syndrome? / Bedogni, Giorgio; Grugni, Graziano; Nobili, Valerio; Agosti, Fiorenza; Saezza, Antonella; Sartorio, Alessandro.

In: Obesity Facts, Vol. 7, No. 1, 2014, p. 71-76.

Research output: Contribution to journalArticle

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AU - Saezza, Antonella

AU - Sartorio, Alessandro

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N2 - Objective: Patients with Prader-Willi syndrome (PWS) have been hypothesized to be at lower risk of non-alcoholic fatty liver disease (NAFLD) because of higher insulin sensitivity. However, PWS patients have a peculiar body composition, i.e. higher fat mass and lower fat-free mass, which may confound such associations. We evaluated whether NAFLD is less frequent in PWS than in non-PWS women matched on percent body fat (PBF). Methods: PBF was measured by dual-energy X-ray absorptiometry. Liver fat was assessed by ultrasonography. Insulin sensitivity and beta-cell function were evaluated by oral glucose tolerance testing. Coarsened exact matching (CEM) was used to match PWS and non-PWS women on PBF. General and generalized linear models taking CEM into account were used to perform comparisons between PWS and non-PWS women. Results: 20 women with PWS were matched to 27 women without PWS on the basis of PBF (mean 53 vs. 54%, p = 0.6). Insulin sensitivity and beta-cell function were similar in the two groups. However, the prevalence of NAFLD was 25% in PWS versus 59% in non-PWS women (p = 0.04). Conclusion: NAFLD is less frequent in PWS than in non-PWS women but this finding is not associated with higher insulin sensitivity.

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