Is nuclear styrene monooxygenase activity a microsomal artifact?

E. Garattini, G. Gazzotti, M. Salmona

Research output: Contribution to journalArticle

Abstract

Microsomal contamination in nuclear preparations could represent one of the main sources of bias in the evaluation of the real metabolic capacity of the nuclear envelope. In this paper the authors present a quantitative study of the level of nuclear styrene monooxygenase enzymatic activity after artificially increasing the native microsomes to nuclei ratio. In the experimental conditions no significant elevation of the nuclear monooxygenase was observed. These data indicate that, if any microsomal contamination is present, it cannot account for more than 30% of the total enzymatic activity found in nuclear preparations.

Original languageEnglish
Pages (from-to)341-346
Number of pages6
JournalChemico-Biological Interactions
Volume31
Issue number3
DOIs
Publication statusPublished - 1980

ASJC Scopus subject areas

  • Toxicology

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