L'obésité est-elle une maladie inflammatoire?

Translated title of the contribution: Is obesity an inflammatory illness?

Rafaella Cancello, Karine Clément

Research output: Contribution to journalArticlepeer-review

Abstract

There are at least two scientific indications that human obesity might be a chonic inflammatory illness: first, the well-described moderate increase of inflammatory factors in the circulation in obese subjects, and second, the recent identification of macrophage cells infiltrating the white adipose tissue (WAT). These observations led to a revision of the physiopathology of obesity and its co-morbidities. It has been suggested that the "low-grade" inflammatory state associates with metabolic and cardiovascular complications of obesity. Weight loss is able to improve this inflammatory state by both significantly decreasing circulating inflammatory molecules and macrophage cell infiltration in WAT deposits. However, the mechanisms of WAT macrophage recruitment into the adipose tissue and their role in obesity complications have not been defined. This review aims to point out the knowledge on inflammatory cytokines associated with obesity and focuses on macrophage infiltration in human WAT, discussing their recruitment and role. The interactions of macrophages with adipocytes will certainly be the subject of intense investigations in the future.

Translated title of the contributionIs obesity an inflammatory illness?
Original languageFrench
Pages (from-to)18-23
Number of pages6
JournalMedecine Therapeutique - Cardio
Volume3
Issue number1
DOIs
Publication statusPublished - Jan 2007

Keywords

  • Inflammation
  • Macrophage
  • Obesity
  • White adipose tissue

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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