Is PML a tumor suppressor?

Massimiliano Mazza, Pier Giuseppe Pelicci

Research output: Contribution to journalArticlepeer-review

Abstract

The role of the promyelocytic leukemia (PML) protein has been widely tested in many different contexts, as attested by the hundreds of papers present in the literature. In most of these studies, PML is regarded as a tumor suppressor, a notion on the whole accepted by the scientific community. In this review, we examine how the concept of tumor-suppressor gene has evolved until now and then systematically assess whether this assumption for PML is supported by unambiguous experimental evidence.

Original languageEnglish
Article number00174
JournalFrontiers in Oncology
Volume3 JUL
DOIs
Publication statusPublished - 2013

Keywords

  • Cancer
  • Cancer stem cells
  • Cancer therapy
  • PML
  • Tumor suppressor

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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