Is PML a tumor suppressor?

Massimiliano Mazza, Pier Giuseppe Pelicci

Research output: Contribution to journalArticle

Abstract

The role of the promyelocytic leukemia (PML) protein has been widely tested in many different contexts, as attested by the hundreds of papers present in the literature. In most of these studies, PML is regarded as a tumor suppressor, a notion on the whole accepted by the scientific community. In this review, we examine how the concept of tumor-suppressor gene has evolved until now and then systematically assess whether this assumption for PML is supported by unambiguous experimental evidence.

Original languageEnglish
Article number00174
JournalFrontiers in Oncology
Volume3 JUL
DOIs
Publication statusPublished - 2013

Fingerprint

Leukemia
Tumor Suppressor Genes
Neoplasms
Promyelocytic Leukemia Protein

Keywords

  • Cancer
  • Cancer stem cells
  • Cancer therapy
  • PML
  • Tumor suppressor

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Is PML a tumor suppressor? / Mazza, Massimiliano; Pelicci, Pier Giuseppe.

In: Frontiers in Oncology, Vol. 3 JUL, 00174, 2013.

Research output: Contribution to journalArticle

Mazza, Massimiliano ; Pelicci, Pier Giuseppe. / Is PML a tumor suppressor?. In: Frontiers in Oncology. 2013 ; Vol. 3 JUL.
@article{104ccc7464494452a72b4e9afae5e535,
title = "Is PML a tumor suppressor?",
abstract = "The role of the promyelocytic leukemia (PML) protein has been widely tested in many different contexts, as attested by the hundreds of papers present in the literature. In most of these studies, PML is regarded as a tumor suppressor, a notion on the whole accepted by the scientific community. In this review, we examine how the concept of tumor-suppressor gene has evolved until now and then systematically assess whether this assumption for PML is supported by unambiguous experimental evidence.",
keywords = "Cancer, Cancer stem cells, Cancer therapy, PML, Tumor suppressor",
author = "Massimiliano Mazza and Pelicci, {Pier Giuseppe}",
year = "2013",
doi = "10.3389/fonc.2013.00174",
language = "English",
volume = "3 JUL",
journal = "Frontiers in Oncology",
issn = "2234-943X",
publisher = "Frontiers Media S. A.",

}

TY - JOUR

T1 - Is PML a tumor suppressor?

AU - Mazza, Massimiliano

AU - Pelicci, Pier Giuseppe

PY - 2013

Y1 - 2013

N2 - The role of the promyelocytic leukemia (PML) protein has been widely tested in many different contexts, as attested by the hundreds of papers present in the literature. In most of these studies, PML is regarded as a tumor suppressor, a notion on the whole accepted by the scientific community. In this review, we examine how the concept of tumor-suppressor gene has evolved until now and then systematically assess whether this assumption for PML is supported by unambiguous experimental evidence.

AB - The role of the promyelocytic leukemia (PML) protein has been widely tested in many different contexts, as attested by the hundreds of papers present in the literature. In most of these studies, PML is regarded as a tumor suppressor, a notion on the whole accepted by the scientific community. In this review, we examine how the concept of tumor-suppressor gene has evolved until now and then systematically assess whether this assumption for PML is supported by unambiguous experimental evidence.

KW - Cancer

KW - Cancer stem cells

KW - Cancer therapy

KW - PML

KW - Tumor suppressor

UR - http://www.scopus.com/inward/record.url?scp=84891107383&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84891107383&partnerID=8YFLogxK

U2 - 10.3389/fonc.2013.00174

DO - 10.3389/fonc.2013.00174

M3 - Article

AN - SCOPUS:84891107383

VL - 3 JUL

JO - Frontiers in Oncology

JF - Frontiers in Oncology

SN - 2234-943X

M1 - 00174

ER -