Is propionibacterium acnes related to disc degeneration in adults?

Pedro Berjano, Jorge H Villafañe, Dario Lo Re, Maryem Fama Ismael, Marco Damilano, Lucia Bertozzi, Carlo L Romanò, Lorenzo Drago

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Abstract

INTRODUCTION: To systematically review the evidence linking Propionibacterium acnes with the development of symptomatic degenerative disc disease.EVIDENCE ACQUISITION: Data were obtained from MEDLINE from their inception to October 2015. Two authors independently conducted the searches, extracted data and completed methodological quality assessments. Articles were included if they investigated the presence of P. acnes in symptomatic degenerative disc disease through intra- operative cultural examination. The methodological quality of the studies was evaluated using the Newcastle-Ottawa scale.EVIDENCE SYNTHESIS: Overall 641 articles were retrieved with 9 cross-sectional studies being included in the review. All selected studies revealed an association between P. acnes and disc degeneration.CONCLUSIONS: This study shows that there is a relationship between P. acnes and development of symptomatic degenerative disc disease. Despite this, we cannot support that P. acnes and development of symptomatic degenerative disc disease due to the low quality of the results according Grading of Recommendations Assessment, Development and Evaluation (GRADE).
Original languageEnglish
JournalJournal of Neurosurgical Sciences
Early online dateSep 7 2016
Publication statusPublished - Apr 2019

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Intervertebral Disc Degeneration
Propionibacterium acnes
MEDLINE
Cross-Sectional Studies

Keywords

  • Journal Article

Cite this

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title = "Is propionibacterium acnes related to disc degeneration in adults?",
abstract = "INTRODUCTION: To systematically review the evidence linking Propionibacterium acnes with the development of symptomatic degenerative disc disease.EVIDENCE ACQUISITION: Data were obtained from MEDLINE from their inception to October 2015. Two authors independently conducted the searches, extracted data and completed methodological quality assessments. Articles were included if they investigated the presence of P. acnes in symptomatic degenerative disc disease through intra- operative cultural examination. The methodological quality of the studies was evaluated using the Newcastle-Ottawa scale.EVIDENCE SYNTHESIS: Overall 641 articles were retrieved with 9 cross-sectional studies being included in the review. All selected studies revealed an association between P. acnes and disc degeneration.CONCLUSIONS: This study shows that there is a relationship between P. acnes and development of symptomatic degenerative disc disease. Despite this, we cannot support that P. acnes and development of symptomatic degenerative disc disease due to the low quality of the results according Grading of Recommendations Assessment, Development and Evaluation (GRADE).",
keywords = "Journal Article",
author = "Pedro Berjano and Villafa{\~n}e, {Jorge H} and {Lo Re}, Dario and Ismael, {Maryem Fama} and Marco Damilano and Lucia Bertozzi and Roman{\`o}, {Carlo L} and Lorenzo Drago",
year = "2019",
month = "4",
language = "English",
journal = "Journal of Neurosurgical Sciences",
issn = "0026-4881",
publisher = "Edizioni Minerva Medica S.p.A.",

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TY - JOUR

T1 - Is propionibacterium acnes related to disc degeneration in adults?

AU - Berjano, Pedro

AU - Villafañe, Jorge H

AU - Lo Re, Dario

AU - Ismael, Maryem Fama

AU - Damilano, Marco

AU - Bertozzi, Lucia

AU - Romanò, Carlo L

AU - Drago, Lorenzo

PY - 2019/4

Y1 - 2019/4

N2 - INTRODUCTION: To systematically review the evidence linking Propionibacterium acnes with the development of symptomatic degenerative disc disease.EVIDENCE ACQUISITION: Data were obtained from MEDLINE from their inception to October 2015. Two authors independently conducted the searches, extracted data and completed methodological quality assessments. Articles were included if they investigated the presence of P. acnes in symptomatic degenerative disc disease through intra- operative cultural examination. The methodological quality of the studies was evaluated using the Newcastle-Ottawa scale.EVIDENCE SYNTHESIS: Overall 641 articles were retrieved with 9 cross-sectional studies being included in the review. All selected studies revealed an association between P. acnes and disc degeneration.CONCLUSIONS: This study shows that there is a relationship between P. acnes and development of symptomatic degenerative disc disease. Despite this, we cannot support that P. acnes and development of symptomatic degenerative disc disease due to the low quality of the results according Grading of Recommendations Assessment, Development and Evaluation (GRADE).

AB - INTRODUCTION: To systematically review the evidence linking Propionibacterium acnes with the development of symptomatic degenerative disc disease.EVIDENCE ACQUISITION: Data were obtained from MEDLINE from their inception to October 2015. Two authors independently conducted the searches, extracted data and completed methodological quality assessments. Articles were included if they investigated the presence of P. acnes in symptomatic degenerative disc disease through intra- operative cultural examination. The methodological quality of the studies was evaluated using the Newcastle-Ottawa scale.EVIDENCE SYNTHESIS: Overall 641 articles were retrieved with 9 cross-sectional studies being included in the review. All selected studies revealed an association between P. acnes and disc degeneration.CONCLUSIONS: This study shows that there is a relationship between P. acnes and development of symptomatic degenerative disc disease. Despite this, we cannot support that P. acnes and development of symptomatic degenerative disc disease due to the low quality of the results according Grading of Recommendations Assessment, Development and Evaluation (GRADE).

KW - Journal Article

M3 - Article

JO - Journal of Neurosurgical Sciences

JF - Journal of Neurosurgical Sciences

SN - 0026-4881

ER -