TY - JOUR
T1 - Is pulmonary function damaged by neoadjuvant lung cancer therapy? A comprehensive serial time-trend analysis of pulmonary function after induction radiochemotherapy plus surgery
AU - Margaritora, S.
AU - Cesario, A.
AU - Cusumano, G.
AU - Cafarotti, S.
AU - Corbo, G. M.
AU - Ferri, L.
AU - Ceppi, M.
AU - Meacci, E.
AU - Valente, S.
AU - D'Angelillo, R. M.
AU - Russo, P.
AU - Porziella, V.
AU - Bonassi, S.
AU - Pasqua, F.
AU - Sterzi, S.
AU - Granone, P.
PY - 2010/6
Y1 - 2010/6
N2 - Objective: We have analyzed short- and long-term variations of pulmonary function in locally advanced non-small cell lung cancer after induction chemoradiotherapy. Methods: Twenty-seven patients with stage IIIA (N2) non-small cell lung cancer underwent resection with radical intent after induction chemoradiotherapy in the period 2003 to 2006. Pulmonary function has been evaluated by spirometry, diffusing capacity of the lung for carbon monoxide, and blood gas analysis before induction chemoradiotherapy (T0), 4 weeks after induction chemoradiotherapy and before surgery (T1), and 1 (T2), 3 (T3), 6 (T4), and 12 months (T5) after surgery. Results: A 22.80% decrease of diffusing capacity of the lung for carbon monoxide (P <.001) was observed at T1. At T2 significant decreases in the following were present: vital capacity, -20.50% (P <.001); forced vital capacity, -22.50% (P <.001); forced expiratory volume in 1 second, -23.00% (P <.001); peak expiratory flow, -29.0 (P
AB - Objective: We have analyzed short- and long-term variations of pulmonary function in locally advanced non-small cell lung cancer after induction chemoradiotherapy. Methods: Twenty-seven patients with stage IIIA (N2) non-small cell lung cancer underwent resection with radical intent after induction chemoradiotherapy in the period 2003 to 2006. Pulmonary function has been evaluated by spirometry, diffusing capacity of the lung for carbon monoxide, and blood gas analysis before induction chemoradiotherapy (T0), 4 weeks after induction chemoradiotherapy and before surgery (T1), and 1 (T2), 3 (T3), 6 (T4), and 12 months (T5) after surgery. Results: A 22.80% decrease of diffusing capacity of the lung for carbon monoxide (P <.001) was observed at T1. At T2 significant decreases in the following were present: vital capacity, -20.50% (P <.001); forced vital capacity, -22.50% (P <.001); forced expiratory volume in 1 second, -23.00% (P <.001); peak expiratory flow, -29.0 (P
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U2 - 10.1016/j.jtcvs.2009.10.023
DO - 10.1016/j.jtcvs.2009.10.023
M3 - Article
C2 - 20363001
AN - SCOPUS:77952320364
VL - 139
SP - 1457
EP - 1463
JO - Journal of Thoracic and Cardiovascular Surgery
JF - Journal of Thoracic and Cardiovascular Surgery
SN - 0022-5223
IS - 6
ER -