Is pulmonary function damaged by neoadjuvant lung cancer therapy? A comprehensive serial time-trend analysis of pulmonary function after induction radiochemotherapy plus surgery

S. Margaritora, A. Cesario, G. Cusumano, S. Cafarotti, G. M. Corbo, L. Ferri, M. Ceppi, E. Meacci, S. Valente, R. M. D'Angelillo, P. Russo, V. Porziella, S. Bonassi, F. Pasqua, S. Sterzi, P. Granone

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: We have analyzed short- and long-term variations of pulmonary function in locally advanced non-small cell lung cancer after induction chemoradiotherapy. Methods: Twenty-seven patients with stage IIIA (N2) non-small cell lung cancer underwent resection with radical intent after induction chemoradiotherapy in the period 2003 to 2006. Pulmonary function has been evaluated by spirometry, diffusing capacity of the lung for carbon monoxide, and blood gas analysis before induction chemoradiotherapy (T0), 4 weeks after induction chemoradiotherapy and before surgery (T1), and 1 (T2), 3 (T3), 6 (T4), and 12 months (T5) after surgery. Results: A 22.80% decrease of diffusing capacity of the lung for carbon monoxide (P <.001) was observed at T1. At T2 significant decreases in the following were present: vital capacity, -20.50% (P <.001); forced vital capacity, -22.50% (P <.001); forced expiratory volume in 1 second, -23.00% (P <.001); peak expiratory flow, -29.0 (P 

Original languageEnglish
Pages (from-to)1457-1463
Number of pages7
JournalJournal of Thoracic and Cardiovascular Surgery
Volume139
Issue number6
DOIs
Publication statusPublished - Jun 2010

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Pulmonary and Respiratory Medicine

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