Is pulmonary function damaged by neoadjuvant lung cancer therapy? A comprehensive serial time-trend analysis of pulmonary function after induction radiochemotherapy plus surgery

S. Margaritora; A. Cesario; G. Cusumano; S. Cafarotti; G. M. Corbo; L. Ferri; M. Ceppi; E. Meacci; S. Valente; R. M. D'Angelillo; P. Russo; V. Porziella; S. Bonassi; F. Pasqua; S. Sterzi; P. Granone

doi:10.1016/j.jtcvs.2009.10.023

Is pulmonary function damaged by neoadjuvant lung cancer therapy? A comprehensive serial time-trend analysis of pulmonary function after induction radiochemotherapy plus surgery

S. Margaritora, A. Cesario, G. Cusumano, S. Cafarotti, G. M. Corbo, L. Ferri, M. Ceppi, E. Meacci, S. Valente, R. M. D'Angelillo, P. Russo, V. Porziella, S. Bonassi, F. Pasqua, S. Sterzi, P. Granone

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: We have analyzed short- and long-term variations of pulmonary function in locally advanced non-small cell lung cancer after induction chemoradiotherapy. Methods: Twenty-seven patients with stage IIIA (N2) non-small cell lung cancer underwent resection with radical intent after induction chemoradiotherapy in the period 2003 to 2006. Pulmonary function has been evaluated by spirometry, diffusing capacity of the lung for carbon monoxide, and blood gas analysis before induction chemoradiotherapy (T0), 4 weeks after induction chemoradiotherapy and before surgery (T1), and 1 (T2), 3 (T3), 6 (T4), and 12 months (T5) after surgery. Results: A 22.80% decrease of diffusing capacity of the lung for carbon monoxide (P <.001) was observed at T1. At T2 significant decreases in the following were present: vital capacity, -20.50% (P <.001); forced vital capacity, -22.50% (P <.001); forced expiratory volume in 1 second, -23.00% (P <.001); peak expiratory flow, -29.0 (P

Original language	English
Pages (from-to)	1457-1463
Number of pages	7
Journal	Journal of Thoracic and Cardiovascular Surgery
Volume	139
Issue number	6
DOIs	https://doi.org/10.1016/j.jtcvs.2009.10.023
Publication status	Published - Jun 2010

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Surgery
Pulmonary and Respiratory Medicine

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Margaritora, S., Cesario, A., Cusumano, G., Cafarotti, S., Corbo, G. M., Ferri, L., Ceppi, M., Meacci, E., Valente, S., D'Angelillo, R. M., Russo, P., Porziella, V., Bonassi, S., Pasqua, F., Sterzi, S., & Granone, P. (2010). Is pulmonary function damaged by neoadjuvant lung cancer therapy? A comprehensive serial time-trend analysis of pulmonary function after induction radiochemotherapy plus surgery. Journal of Thoracic and Cardiovascular Surgery, 139(6), 1457-1463. https://doi.org/10.1016/j.jtcvs.2009.10.023

Is pulmonary function damaged by neoadjuvant lung cancer therapy? A comprehensive serial time-trend analysis of pulmonary function after induction radiochemotherapy plus surgery. / Margaritora, S.; Cesario, A.; Cusumano, G.; Cafarotti, S.; Corbo, G. M.; Ferri, L.; Ceppi, M.; Meacci, E.; Valente, S.; D'Angelillo, R. M.; Russo, P.; Porziella, V.; Bonassi, S.; Pasqua, F.; Sterzi, S.; Granone, P.

In: Journal of Thoracic and Cardiovascular Surgery, Vol. 139, No. 6, 06.2010, p. 1457-1463.

Research output: Contribution to journal › Article › peer-review

Margaritora, S, Cesario, A, Cusumano, G, Cafarotti, S, Corbo, GM, Ferri, L, Ceppi, M, Meacci, E, Valente, S, D'Angelillo, RM, Russo, P, Porziella, V, Bonassi, S, Pasqua, F, Sterzi, S & Granone, P 2010, 'Is pulmonary function damaged by neoadjuvant lung cancer therapy? A comprehensive serial time-trend analysis of pulmonary function after induction radiochemotherapy plus surgery', Journal of Thoracic and Cardiovascular Surgery, vol. 139, no. 6, pp. 1457-1463. https://doi.org/10.1016/j.jtcvs.2009.10.023

Margaritora S, Cesario A, Cusumano G, Cafarotti S, Corbo GM, Ferri L et al. Is pulmonary function damaged by neoadjuvant lung cancer therapy? A comprehensive serial time-trend analysis of pulmonary function after induction radiochemotherapy plus surgery. Journal of Thoracic and Cardiovascular Surgery. 2010 Jun;139(6):1457-1463. https://doi.org/10.1016/j.jtcvs.2009.10.023

Margaritora, S. ; Cesario, A. ; Cusumano, G. ; Cafarotti, S. ; Corbo, G. M. ; Ferri, L. ; Ceppi, M. ; Meacci, E. ; Valente, S. ; D'Angelillo, R. M. ; Russo, P. ; Porziella, V. ; Bonassi, S. ; Pasqua, F. ; Sterzi, S. ; Granone, P. / Is pulmonary function damaged by neoadjuvant lung cancer therapy? A comprehensive serial time-trend analysis of pulmonary function after induction radiochemotherapy plus surgery. In: Journal of Thoracic and Cardiovascular Surgery. 2010 ; Vol. 139, No. 6. pp. 1457-1463.

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abstract = "Objective: We have analyzed short- and long-term variations of pulmonary function in locally advanced non-small cell lung cancer after induction chemoradiotherapy. Methods: Twenty-seven patients with stage IIIA (N2) non-small cell lung cancer underwent resection with radical intent after induction chemoradiotherapy in the period 2003 to 2006. Pulmonary function has been evaluated by spirometry, diffusing capacity of the lung for carbon monoxide, and blood gas analysis before induction chemoradiotherapy (T0), 4 weeks after induction chemoradiotherapy and before surgery (T1), and 1 (T2), 3 (T3), 6 (T4), and 12 months (T5) after surgery. Results: A 22.80% decrease of diffusing capacity of the lung for carbon monoxide (P <.001) was observed at T1. At T2 significant decreases in the following were present: vital capacity, -20.50% (P <.001); forced vital capacity, -22.50% (P <.001); forced expiratory volume in 1 second, -23.00% (P <.001); peak expiratory flow, -29.0 (P ",

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AU - Cesario, A.

AU - Cusumano, G.

AU - Cafarotti, S.

AU - Corbo, G. M.

AU - Ferri, L.

AU - Ceppi, M.

AU - Meacci, E.

AU - Valente, S.

AU - D'Angelillo, R. M.

AU - Russo, P.

AU - Porziella, V.

AU - Bonassi, S.

AU - Pasqua, F.

AU - Sterzi, S.

AU - Granone, P.

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N2 - Objective: We have analyzed short- and long-term variations of pulmonary function in locally advanced non-small cell lung cancer after induction chemoradiotherapy. Methods: Twenty-seven patients with stage IIIA (N2) non-small cell lung cancer underwent resection with radical intent after induction chemoradiotherapy in the period 2003 to 2006. Pulmonary function has been evaluated by spirometry, diffusing capacity of the lung for carbon monoxide, and blood gas analysis before induction chemoradiotherapy (T0), 4 weeks after induction chemoradiotherapy and before surgery (T1), and 1 (T2), 3 (T3), 6 (T4), and 12 months (T5) after surgery. Results: A 22.80% decrease of diffusing capacity of the lung for carbon monoxide (P <.001) was observed at T1. At T2 significant decreases in the following were present: vital capacity, -20.50% (P <.001); forced vital capacity, -22.50% (P <.001); forced expiratory volume in 1 second, -23.00% (P <.001); peak expiratory flow, -29.0 (P

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