Is re-challenge still an option as salvage therapy in multiple myeloma? The case of REal-life BOrtezomib re-Use as secoND treatment for relapsed patients exposed frontline to bortezomib-based therapies (the REBOUND Study)

Pellegrino Musto, Vittorio Simeon, Nicola Cascavilla, Antonietta Falcone, Maria Teresa Petrucci, Laura Cesini, Francesco Di Raimondo, Concetta Conticello, Roberto Ria, Lucio Catalano, Dalila Salvatore, Lucia Mastrullo, Alfredo Gagliardi, Oreste Villani, Giuseppe Pietrantuono, Giovanni D'Arena, Giovanna Mansueto, Sara Bringhen, Mariella Genuardi, Nicola Di RenzoGiovanni Reddiconto, Alberto Fragasso, Tommaso Caravita, Daniele Scapicchio, Gioacchino Marziano, Mario Boccadoro, Silvia Mangiacavalli, Alessandro Corso

Research output: Contribution to journalArticle


Therapeutic re-challenge is currently a debated issue in the field of multiple myeloma (MM), given the recent availability of several new drugs and combinations. However, very few specific evidences are available about bortezomib re-use at first relapse. This multicenter, observational, retrospective study enrolled 134 MM patients with significant response after bortezomib-based frontline regimens and who had received a first salvage treatment containing bortezomib at relapse. The overall response rate was 71%, including 40% partial responses, 24% very good partial responses, and 7% complete responses. Re-treatment was well-tolerated, with no significant new or unexpected toxicities observed. The median duration of second progression-free survival (PFS) was 15 months, while median PFS2 was 55 months. With a median follow-up of 56 months, overall survival was 94 months for the entire series, without significant differences between patients undergoing or not undergoing transplant procedures. This real-life survey indicates that re-treatment including bortezomib as a first salvage therapy could be still considered in MM patients achieving durable response after initial exposure to bortezomib.
Original languageEnglish
Pages (from-to)361-367
Number of pages7
JournalAnnals of Hematology
Issue number2
Publication statusPublished - Feb 2019



  • Bortezomib
  • First relapse
  • Myeloma
  • Re-treatment
  • Salvage therapy
  • Aged
  • Bortezomib/*administration & dosage/adverse effects
  • Disease-Free Survival
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Multiple Myeloma/*drug therapy/*mortality/pathology
  • Recurrence
  • Retrospective Studies
  • *Salvage Therapy
  • Survival Rate

Cite this