Is robot-assisted radical prostatectomy safe in men with high-risk prostate cancer? assessment of perioperative outcomes, positive surgical margins, and use of additional cancer treatments

Giorgio Gandaglia, Firas Abdollah, Jim Hu, Simon Kim, Alberto Briganti, Jesse D. Sammon, Andreas Becker, Florian Roghmann, Markus Graefen, Francesco Montorsi, Paul Perrotte, Pierre I. Karakiewicz, Quoc Dien Trinh, Maxine Sun

Research output: Contribution to journalArticle

Abstract

Introduction: Despite a rapid dissemination of robot-assisted radical prostatectomy (RARP) over open radical prostatectomy (ORP), to date no study has compared perioperative outcomes between the two approaches in patients with high-risk prostate cancer (PCa). The aim of our study was to evaluate the safety and feasibility of RARP in this setting. Patients and Methods: Overall, 1,512 patients with high-risk PCa within the Surveillance, Epidemiology, and End Results (SEER) Medicare-linked database diagnosed between 2008 and 2009 were abstracted. Patients were treated with RARP or ORP. Postoperative complications, blood transfusions, prolonged length of stay (pLOS), positive surgical margins, and additional cancer therapy rates were compared. Propensity-score matched analyses and logistic regression models fitted with generalized estimating equations for clustering among hospitals were performed. Results: Overall, 706 (46.7%) and 806 (53.3%) patients underwent ORP and RARP, respectively. Following propensity-matched analyses, 706 patients remained. No differences were observed in complications (P=0.6), positive surgical margins (P=0.4), or additional therapy after surgery (P=0.2) between patients treated with RARP and ORP; however, RARP was associated with lower rates of transfusions and shorter hospitalization (all P

Original languageEnglish
Pages (from-to)784-791
Number of pages8
JournalJournal of Endourology
Volume28
Issue number7
DOIs
Publication statusPublished - Jul 1 2014

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Prostatectomy
Prostatic Neoplasms
Outcome Assessment (Health Care)
Neoplasms
Therapeutics
Logistic Models
Margins of Excision
Propensity Score
Medicare
Blood Transfusion
Cluster Analysis
Length of Stay
Epidemiology
Hospitalization
Databases
Safety

ASJC Scopus subject areas

  • Urology

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Is robot-assisted radical prostatectomy safe in men with high-risk prostate cancer? assessment of perioperative outcomes, positive surgical margins, and use of additional cancer treatments. / Gandaglia, Giorgio; Abdollah, Firas; Hu, Jim; Kim, Simon; Briganti, Alberto; Sammon, Jesse D.; Becker, Andreas; Roghmann, Florian; Graefen, Markus; Montorsi, Francesco; Perrotte, Paul; Karakiewicz, Pierre I.; Trinh, Quoc Dien; Sun, Maxine.

In: Journal of Endourology, Vol. 28, No. 7, 01.07.2014, p. 784-791.

Research output: Contribution to journalArticle

Gandaglia, Giorgio ; Abdollah, Firas ; Hu, Jim ; Kim, Simon ; Briganti, Alberto ; Sammon, Jesse D. ; Becker, Andreas ; Roghmann, Florian ; Graefen, Markus ; Montorsi, Francesco ; Perrotte, Paul ; Karakiewicz, Pierre I. ; Trinh, Quoc Dien ; Sun, Maxine. / Is robot-assisted radical prostatectomy safe in men with high-risk prostate cancer? assessment of perioperative outcomes, positive surgical margins, and use of additional cancer treatments. In: Journal of Endourology. 2014 ; Vol. 28, No. 7. pp. 784-791.
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AU - Hu, Jim

AU - Kim, Simon

AU - Briganti, Alberto

AU - Sammon, Jesse D.

AU - Becker, Andreas

AU - Roghmann, Florian

AU - Graefen, Markus

AU - Montorsi, Francesco

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AU - Trinh, Quoc Dien

AU - Sun, Maxine

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