Is robot-assisted radical prostatectomy safe in men with high-risk prostate cancer? assessment of perioperative outcomes, positive surgical margins, and use of additional cancer treatments

Giorgio Gandaglia, Firas Abdollah, Jim Hu, Simon Kim, Alberto Briganti, Jesse D. Sammon, Andreas Becker, Florian Roghmann, Markus Graefen, Francesco Montorsi, Paul Perrotte, Pierre I. Karakiewicz, Quoc Dien Trinh, Maxine Sun

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Despite a rapid dissemination of robot-assisted radical prostatectomy (RARP) over open radical prostatectomy (ORP), to date no study has compared perioperative outcomes between the two approaches in patients with high-risk prostate cancer (PCa). The aim of our study was to evaluate the safety and feasibility of RARP in this setting. Patients and Methods: Overall, 1,512 patients with high-risk PCa within the Surveillance, Epidemiology, and End Results (SEER) Medicare-linked database diagnosed between 2008 and 2009 were abstracted. Patients were treated with RARP or ORP. Postoperative complications, blood transfusions, prolonged length of stay (pLOS), positive surgical margins, and additional cancer therapy rates were compared. Propensity-score matched analyses and logistic regression models fitted with generalized estimating equations for clustering among hospitals were performed. Results: Overall, 706 (46.7%) and 806 (53.3%) patients underwent ORP and RARP, respectively. Following propensity-matched analyses, 706 patients remained. No differences were observed in complications (P=0.6), positive surgical margins (P=0.4), or additional therapy after surgery (P=0.2) between patients treated with RARP and ORP; however, RARP was associated with lower rates of transfusions and shorter hospitalization (all P

Original languageEnglish
Pages (from-to)784-791
Number of pages8
JournalJournal of Endourology
Volume28
Issue number7
DOIs
Publication statusPublished - Jul 1 2014

ASJC Scopus subject areas

  • Urology

Fingerprint Dive into the research topics of 'Is robot-assisted radical prostatectomy safe in men with high-risk prostate cancer? assessment of perioperative outcomes, positive surgical margins, and use of additional cancer treatments'. Together they form a unique fingerprint.

Cite this