Is seborrhea a sign of autonomic impairment in Parkinson's disease?

E. Martignoni, L. Godi, C. Pacchetti, E. Berardesca, G. P. Vignoli, G. Albani, F. Mancini, G. Nappi

Research output: Contribution to journalArticlepeer-review


An increase of sebum excretion rate (SER) is frequently observed in patients suffering from Parkinson's disease (PD). Some authors attribute it to the hyperactivity of the parasympathetic system, while others consider the possible action of androgens or of MSH-hormone. The aim of our study was to verify and quantify SER in 70 parkinsonian patients and compare it with SER in 60 normal subjects. We found higher values of SER in male subjects, both in normal and in parkinsonian patients. The highest rate of excretion was observed in parkinsonian males, in agreement with the possible main role of androgens or testosterone in sebum excretion, while the phenomenon did not appear to be related to abnormalities of the autonomic nervous system. The association of PD and sex hormones might therefore be crucial for the developing of seborrhea.

Original languageEnglish
Pages (from-to)1295-1304
Number of pages10
JournalJournal of Neural Transmission
Issue number11-12
Publication statusPublished - 1997


  • Autonomic nervous system
  • Parkinson's disease
  • Seborrhea

ASJC Scopus subject areas

  • Neuroscience(all)


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