Abstract
Citrulline (CIT), a non-protein amino acid in circulating blood, is almost exclusively contained in the enterocytes of small bowel mucosa and may represent a reliable marker of functioning enterocyte mass. The aim of this study was to evaluate the clinical utility of measuring serum citrulline levels in a group of patients affected by coeliac disease (CD). Fifty healthy volunteers, 21 patients with untreated coeliac disease and 6 patients with refractory coeliac disease took part in the study. Serum citrulline levels and duodenal lesions were evaluated at the time of diagnosis, and after at least 24 months of gluten-free diet. Serum citrulline concentrations were determined by ion exchange chromatography. In comparison to healthy volunteers, serum citrulline concentrations were significantly lower in untreated and refractory coeliac disease patients. No significant difference was found between untreated and refractory coeliac disease patients and between patients with different patterns of clinical presentation or various degrees of duodenal lesions. After a gluten-free diet, the mean of serum citrulline concentration was increased in all but one patient. Although, as expected, serum citrulline levels turned out to be low in coeliac disease, the clinical utility of their measurement is, at least, questionable in this condition.
| Original language | English |
|---|---|
| Pages (from-to) | 233-236 |
| Number of pages | 4 |
| Journal | Internal and Emergency Medicine |
| Volume | 3 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Sep 2008 |
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Keywords
- Citrulline
- Coeliac disease
- Small bowel disease
- Villous atrophy
ASJC Scopus subject areas
- Emergency Medicine
- Internal Medicine
Cite this
Is serum citrulline measurement clinically useful in coeliac disease? / Miceli, Emanuela; Poggi, Nicoletta; Missanelli, Antonio; Bianchi, Paola; Moratti, Remigio; Corazza, Gino Roberto.
In: Internal and Emergency Medicine, Vol. 3, No. 3, 09.2008, p. 233-236.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Is serum citrulline measurement clinically useful in coeliac disease?
AU - Miceli, Emanuela
AU - Poggi, Nicoletta
AU - Missanelli, Antonio
AU - Bianchi, Paola
AU - Moratti, Remigio
AU - Corazza, Gino Roberto
PY - 2008/9
Y1 - 2008/9
N2 - Citrulline (CIT), a non-protein amino acid in circulating blood, is almost exclusively contained in the enterocytes of small bowel mucosa and may represent a reliable marker of functioning enterocyte mass. The aim of this study was to evaluate the clinical utility of measuring serum citrulline levels in a group of patients affected by coeliac disease (CD). Fifty healthy volunteers, 21 patients with untreated coeliac disease and 6 patients with refractory coeliac disease took part in the study. Serum citrulline levels and duodenal lesions were evaluated at the time of diagnosis, and after at least 24 months of gluten-free diet. Serum citrulline concentrations were determined by ion exchange chromatography. In comparison to healthy volunteers, serum citrulline concentrations were significantly lower in untreated and refractory coeliac disease patients. No significant difference was found between untreated and refractory coeliac disease patients and between patients with different patterns of clinical presentation or various degrees of duodenal lesions. After a gluten-free diet, the mean of serum citrulline concentration was increased in all but one patient. Although, as expected, serum citrulline levels turned out to be low in coeliac disease, the clinical utility of their measurement is, at least, questionable in this condition.
AB - Citrulline (CIT), a non-protein amino acid in circulating blood, is almost exclusively contained in the enterocytes of small bowel mucosa and may represent a reliable marker of functioning enterocyte mass. The aim of this study was to evaluate the clinical utility of measuring serum citrulline levels in a group of patients affected by coeliac disease (CD). Fifty healthy volunteers, 21 patients with untreated coeliac disease and 6 patients with refractory coeliac disease took part in the study. Serum citrulline levels and duodenal lesions were evaluated at the time of diagnosis, and after at least 24 months of gluten-free diet. Serum citrulline concentrations were determined by ion exchange chromatography. In comparison to healthy volunteers, serum citrulline concentrations were significantly lower in untreated and refractory coeliac disease patients. No significant difference was found between untreated and refractory coeliac disease patients and between patients with different patterns of clinical presentation or various degrees of duodenal lesions. After a gluten-free diet, the mean of serum citrulline concentration was increased in all but one patient. Although, as expected, serum citrulline levels turned out to be low in coeliac disease, the clinical utility of their measurement is, at least, questionable in this condition.
KW - Citrulline
KW - Coeliac disease
KW - Small bowel disease
KW - Villous atrophy
UR - http://www.scopus.com/inward/record.url?scp=49649108537&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=49649108537&partnerID=8YFLogxK
U2 - 10.1007/s11739-008-0155-x
DO - 10.1007/s11739-008-0155-x
M3 - Article
C2 - 18437289
AN - SCOPUS:49649108537
VL - 3
SP - 233
EP - 236
JO - Internal and Emergency Medicine
JF - Internal and Emergency Medicine
SN - 1828-0447
IS - 3
ER -