Is serum troponin T a useful marker of myocardial damage in newborn infants with perinatal asphyxia?

S. Costa, E. Zecca, G. De Rosa, D. De Luca, G. Barbato, M. Pardeo, C. Romagnoli

Research output: Contribution to journalArticle

Abstract

Aim: To assess the correlation of echocardiographic signs of myocardial damage to serum cardiac troponin T (cTnT) concentrations in newborn infants with perinatal asphyxia. Methods: Electocardiograms (ECG) and echocardiograms (Echo) were obtained during the first 24 h of life from 29 asphyxiated and 30 control infants and correlated with cTnT concentrations. The echocardiographic parameters included systolic ventricular performance, preload, afterload, diastolic function, stroke volume (SV), left ventricular output (LVO), hyperechogenity of the papillary muscles and insufficiency of the atrioventricular valves. Results: LVO and SV were lower but CTnT were significantly higher in asphyxiated than in control infants: 0.15 (010-0.23) vs. 0.05 (0.02-0.13), p <0.001). Asphyxiated infants with signs of myocardial damage were associated with significantly higher cTnT than those without, 0.20 (0.11-0.28) and 0.11 (0.05-0.14 ug/L), p = 0.04. Conclusion: Cardiac troponin may prove to be valuable in evaluating myocardial damage in birth asphyxia. However, the degree of prematurity may complicate the assessment.

Original languageEnglish
Pages (from-to)181-184
Number of pages4
JournalActa Paediatrica, International Journal of Paediatrics
Volume96
Issue number2
DOIs
Publication statusPublished - Feb 2007

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Keywords

  • Cardiac troponin T
  • Echocardiography
  • Myocardial ischaemia
  • Perinatal asphyxia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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