Is soluble mesothelin-related protein an upfront predictive marker of pleural mesothelioma? A prospective study on Italian workers exposed to asbestos

Rosa Filiberti, Paola Marroni, Fabio Spigno, Domenico F. Merlo, Virginia Mortara, Pietro Caruso, Alex Cioè, Luigi Michelazzi, Andrea Bruzzone, Barbara Bobbio, Claudio Simonassi, Lisette Del Corso, Roberto Galli, Omar Racchi, Guglielmo Dini, Roberta Linares, Manlio Mencoboni

Research output: Contribution to journalArticle

Abstract

Objective: Soluble mesothelin-related peptide (SMRP) may be useful in the diagnosis and detection of early stage mesothelioma. We investigated the SMRP upfront predictive role for mesothelioma in asbestos-exposed workers. Methods: A total of 1,715 subjects underwent a first visit and were invited for a follow-up after 1 and 2 years, with a clinical examination and blood sampling. SMRP was measured by an ELISA assay. Results: Median SMRP at the first visit was 0.45 [interquartile range (IQR) i.e. 25th-75th percentile: 0.30-0.67 nmol/l]. In all, 1,676 subjects (97.8%) were followed up for a median period of 47.1 months. SMRP was measured at the first visit and at both follow-up visits in 1,536 subjects. At follow-up, 3 subjects were diagnosed with an epithelioid mesothelioma. In these cases, SMRP at the first visit ranged from 0.17 to 0.52 nmol/l. Malignant pleural mesothelioma was diagnosed 9-17 months after the last SMRP evaluation. No SMRP variation was observed during the follow-up. Other 61 miscellaneous cancers were diagnosed (median SMRP at first visit: 0.50 nmol/l, IQR: 0.34-0.71 nmol/l). Conclusions: Our results did not support the usefulness of SMRP as an early marker for the detection of the disease for a time interval of 1 year.

Original languageEnglish
Pages (from-to)33-43
Number of pages11
JournalOncology
Volume86
Issue number1
DOIs
Publication statusPublished - Jan 2014

Keywords

  • Asbestos exposure
  • Malignant pleural mesothelioma
  • Mesothelin

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Filiberti, R., Marroni, P., Spigno, F., Merlo, D. F., Mortara, V., Caruso, P., Cioè, A., Michelazzi, L., Bruzzone, A., Bobbio, B., Simonassi, C., Del Corso, L., Galli, R., Racchi, O., Dini, G., Linares, R., & Mencoboni, M. (2014). Is soluble mesothelin-related protein an upfront predictive marker of pleural mesothelioma? A prospective study on Italian workers exposed to asbestos. Oncology, 86(1), 33-43. https://doi.org/10.1159/000355687