Is sympathetic neural hyperactivity in chronic heart failure affected by heart transplantation?

M. Elam, R. Casale, M. T. La Rovere, A. Mortara, L. Tavazzi

Research output: Contribution to journalArticlepeer-review

Abstract

It has been suggested that immunosuppression with cyclosporine induces marked sympathetic neural hyperactivity in heart transplant recipients. In the present study the resting level of sympathetic nerve activity was investigated with intraneural recording in nine patients with severe chronic heart failure (NYHA class III-IV despite ongoing therapy) in nine heart-transplanted patients with previous heart failure (NYHA class III-IV) receiving standard low-dose triple-drug immunosuppression and in six age-matched controls without cardiovascular disease. Compared to the control group resting sympathetic nerve discharge was markedly increased in heart failure patients (92±2 vs 60±6 B/100b P

Original languageEnglish
Pages (from-to)521-525
Number of pages5
JournalEuropean Heart Journal
Volume14
Issue number4
Publication statusPublished - 1993

Keywords

  • Chronic heart failure
  • Cyclosporine
  • Heart transplantation
  • Microneurography
  • Sympathetic nerve activity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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