Is the body composition development in premature infants associated with a distinctive nuclear magnetic resonance metabolomic profiling of urine?

Daniela Morniroli, Angelica Dessì, Maria Lorella Giannì, Paola Roggero, Antonio Noto, Luigi Atzori, Milena Lussu, Vassilios Fanos, Fabio Mosca

Research output: Contribution to journalArticle

Abstract

Objective: Preterm infants’ body composition at term-corrected age differs from that of term infants but appears to be similar at the age of 3 months. The aim of this study was to compare the metabolomic pattern of preterm infants at term and at 3 months with that of term infants and to determine its association with body composition development. Method: We designed a pilot study. Growth and body composition were evaluated by an air displacement plethysmography system in 13 preterm infants and seven term newborns at term and at 3 months of corrected age. Urine samples were collected at the same time points and analysed by nuclear magnetic resonance. Results: At term-corrected age, preterm infants showed a higher fat mass percentage compared with that of term newborns, whereas at 3 months of corrected age, the body composition parameters were similar between the groups. At the first time point, nuclear magnetic resonance analysis showed a urinary increase in choline/phosphocholine, betaine and glucose in preterm infants. At the second time point, the preterm group exhibited a urinary increase in choline/phosphocholine and a decrease in betaine. Conclusions: The increased urinary excretion of choline, a betaine precursor, could reflect a potential altered metabolism in preterm infants.

Original languageEnglish
Pages (from-to)2310-2318
Number of pages9
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume32
Issue number14
DOIs
Publication statusPublished - 2019

Keywords

  • Body composition
  • metabolomics
  • preterm

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology

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