Is the CACNA1A gene involved in familial migraine with aura?

R. Brugnoni, M. Leone, A. Rigamonti, E. Moranduzzo, F. Cornelio, R. Mantegazza, G. Bussone

Research output: Contribution to journalArticlepeer-review


The discovery of mutations in the neural calcium channel (CACNA1A) gene in familial hemiplegic migraine (FHM), variant of migraine with aura, led to the suggestion that this gene might be involved in familial migraine with aura (FMA). We investigated whether the mutations in FHM are present in FMA patients, analyzing genomic DNA by PCR, single stranded conformation polymorphism, sequencing and restriction enzyme. No mutations were found. A known polymorphism (5682-14C>T) was found in exon 36. These findings suggest that the mutations found in FHM and the other known mutations of the CACNA1A gene are not the genetic basis of FMA. Genetic alterations in FMA patients may be localized on chromosome 19 but not in the CACNA1A exons we investigated.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalNeurological Sciences
Issue number1
Publication statusPublished - 2002


  • CACNA1A gene
  • Familial hemiplegic migraine
  • Migraine with aura
  • Mutation

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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