Is the newest fibrin sealant an effective strategy to reduce blood loss after total knee arthroplasty? A randomized controlled study

Filippo Randelli; Roberto D'Anchise; Vincenza Ragone; Luca Serrao; Paolo Cabitza; Pietro Randelli

doi:10.1016/j.arth.2014.02.024

Is the newest fibrin sealant an effective strategy to reduce blood loss after total knee arthroplasty? A randomized controlled study

Filippo Randelli, Roberto D'Anchise, Vincenza Ragone, Luca Serrao, Paolo Cabitza, Pietro Randelli

IRCCS Policlinico San Donato

Research output: Contribution to journal › Article › peer-review

Abstract

An RCT was conducted to ascertain whether, compared to control management, topical application of a novel fibrin sealant (Evicel, J&J) in patients undergoing primary TKA reduces peri-operative blood loss. Sixty-two patients were randomized to receive topical application of Evicel (N. = 31) or not (N. = 31). The mean total blood loss was 1.9. L(±. 0.7) in the control group and 1.8. L(±. 0.5) in the treatment group (P= 0.4). The transfusion rate was 32.3% in the control group and 25.8% in the treatment group (P= 0.5). The transfusion rate decreased linearly with increasing preoperative Hb levels in the treatment group (P= 0.005). The results of this study suggest that topical application of this novel fibrin sealant doesn't reduce perioperative blood loss and the need for allogeneic blood transfusion.

Original language	English
Pages (from-to)	1516-1520
Number of pages	5
Journal	Journal of Arthroplasty
Volume	29
Issue number	8
DOIs	https://doi.org/10.1016/j.arth.2014.02.024
Publication status	Published - 2014

Keywords

Blood loss
Fibrin sealants
Total knee arthroplasty

ASJC Scopus subject areas

Orthopedics and Sports Medicine

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10.1016/j.arth.2014.02.024

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title = "Is the newest fibrin sealant an effective strategy to reduce blood loss after total knee arthroplasty? A randomized controlled study",

abstract = "An RCT was conducted to ascertain whether, compared to control management, topical application of a novel fibrin sealant (Evicel, J&J) in patients undergoing primary TKA reduces peri-operative blood loss. Sixty-two patients were randomized to receive topical application of Evicel (N. = 31) or not (N. = 31). The mean total blood loss was 1.9. L(±. 0.7) in the control group and 1.8. L(±. 0.5) in the treatment group (P= 0.4). The transfusion rate was 32.3% in the control group and 25.8% in the treatment group (P= 0.5). The transfusion rate decreased linearly with increasing preoperative Hb levels in the treatment group (P= 0.005). The results of this study suggest that topical application of this novel fibrin sealant doesn't reduce perioperative blood loss and the need for allogeneic blood transfusion.",

keywords = "Blood loss, Fibrin sealants, Total knee arthroplasty",

author = "Filippo Randelli and Roberto D'Anchise and Vincenza Ragone and Luca Serrao and Paolo Cabitza and Pietro Randelli",

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AU - Randelli, Filippo

AU - D'Anchise, Roberto

AU - Ragone, Vincenza

AU - Serrao, Luca

AU - Cabitza, Paolo

AU - Randelli, Pietro

PY - 2014

Y1 - 2014

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AB - An RCT was conducted to ascertain whether, compared to control management, topical application of a novel fibrin sealant (Evicel, J&J) in patients undergoing primary TKA reduces peri-operative blood loss. Sixty-two patients were randomized to receive topical application of Evicel (N. = 31) or not (N. = 31). The mean total blood loss was 1.9. L(±. 0.7) in the control group and 1.8. L(±. 0.5) in the treatment group (P= 0.4). The transfusion rate was 32.3% in the control group and 25.8% in the treatment group (P= 0.5). The transfusion rate decreased linearly with increasing preoperative Hb levels in the treatment group (P= 0.005). The results of this study suggest that topical application of this novel fibrin sealant doesn't reduce perioperative blood loss and the need for allogeneic blood transfusion.

KW - Blood loss

KW - Fibrin sealants

KW - Total knee arthroplasty

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Is the newest fibrin sealant an effective strategy to reduce blood loss after total knee arthroplasty? A randomized controlled study

Abstract

Keywords

ASJC Scopus subject areas

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