Abstract
An RCT was conducted to ascertain whether, compared to control management, topical application of a novel fibrin sealant (Evicel, J&J) in patients undergoing primary TKA reduces peri-operative blood loss. Sixty-two patients were randomized to receive topical application of Evicel (N. = 31) or not (N. = 31). The mean total blood loss was 1.9. L(±. 0.7) in the control group and 1.8. L(±. 0.5) in the treatment group (P= 0.4). The transfusion rate was 32.3% in the control group and 25.8% in the treatment group (P= 0.5). The transfusion rate decreased linearly with increasing preoperative Hb levels in the treatment group (P= 0.005). The results of this study suggest that topical application of this novel fibrin sealant doesn't reduce perioperative blood loss and the need for allogeneic blood transfusion.
Original language | English |
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Pages (from-to) | 1516-1520 |
Number of pages | 5 |
Journal | Journal of Arthroplasty |
Volume | 29 |
Issue number | 8 |
DOIs | |
Publication status | Published - 2014 |
Keywords
- Blood loss
- Fibrin sealants
- Total knee arthroplasty
ASJC Scopus subject areas
- Orthopedics and Sports Medicine