Is the newest fibrin sealant an effective strategy to reduce blood loss after total knee arthroplasty? A randomized controlled study

Filippo Randelli, Roberto D'Anchise, Vincenza Ragone, Luca Serrao, Paolo Cabitza, Pietro Randelli

Research output: Contribution to journalArticlepeer-review

Abstract

An RCT was conducted to ascertain whether, compared to control management, topical application of a novel fibrin sealant (Evicel, J&J) in patients undergoing primary TKA reduces peri-operative blood loss. Sixty-two patients were randomized to receive topical application of Evicel (N. = 31) or not (N. = 31). The mean total blood loss was 1.9. L(±. 0.7) in the control group and 1.8. L(±. 0.5) in the treatment group (P= 0.4). The transfusion rate was 32.3% in the control group and 25.8% in the treatment group (P= 0.5). The transfusion rate decreased linearly with increasing preoperative Hb levels in the treatment group (P= 0.005). The results of this study suggest that topical application of this novel fibrin sealant doesn't reduce perioperative blood loss and the need for allogeneic blood transfusion.

Original languageEnglish
Pages (from-to)1516-1520
Number of pages5
JournalJournal of Arthroplasty
Volume29
Issue number8
DOIs
Publication statusPublished - 2014

Keywords

  • Blood loss
  • Fibrin sealants
  • Total knee arthroplasty

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

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