Abstract
An RCT was conducted to ascertain whether, compared to control management, topical application of a novel fibrin sealant (Evicel, J&J) in patients undergoing primary TKA reduces peri-operative blood loss. Sixty-two patients were randomized to receive topical application of Evicel (N. = 31) or not (N. = 31). The mean total blood loss was 1.9. L(±. 0.7) in the control group and 1.8. L(±. 0.5) in the treatment group (P= 0.4). The transfusion rate was 32.3% in the control group and 25.8% in the treatment group (P= 0.5). The transfusion rate decreased linearly with increasing preoperative Hb levels in the treatment group (P= 0.005). The results of this study suggest that topical application of this novel fibrin sealant doesn't reduce perioperative blood loss and the need for allogeneic blood transfusion.
| Original language | English |
|---|---|
| Pages (from-to) | 1516-1520 |
| Number of pages | 5 |
| Journal | Journal of Arthroplasty |
| Volume | 29 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 2014 |
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Keywords
- Blood loss
- Fibrin sealants
- Total knee arthroplasty
ASJC Scopus subject areas
- Orthopedics and Sports Medicine
Cite this
Is the newest fibrin sealant an effective strategy to reduce blood loss after total knee arthroplasty? A randomized controlled study. / Randelli, Filippo; D'Anchise, Roberto; Ragone, Vincenza; Serrao, Luca; Cabitza, Paolo; Randelli, Pietro.
In: Journal of Arthroplasty, Vol. 29, No. 8, 2014, p. 1516-1520.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Is the newest fibrin sealant an effective strategy to reduce blood loss after total knee arthroplasty? A randomized controlled study
AU - Randelli, Filippo
AU - D'Anchise, Roberto
AU - Ragone, Vincenza
AU - Serrao, Luca
AU - Cabitza, Paolo
AU - Randelli, Pietro
PY - 2014
Y1 - 2014
N2 - An RCT was conducted to ascertain whether, compared to control management, topical application of a novel fibrin sealant (Evicel, J&J) in patients undergoing primary TKA reduces peri-operative blood loss. Sixty-two patients were randomized to receive topical application of Evicel (N. = 31) or not (N. = 31). The mean total blood loss was 1.9. L(±. 0.7) in the control group and 1.8. L(±. 0.5) in the treatment group (P= 0.4). The transfusion rate was 32.3% in the control group and 25.8% in the treatment group (P= 0.5). The transfusion rate decreased linearly with increasing preoperative Hb levels in the treatment group (P= 0.005). The results of this study suggest that topical application of this novel fibrin sealant doesn't reduce perioperative blood loss and the need for allogeneic blood transfusion.
AB - An RCT was conducted to ascertain whether, compared to control management, topical application of a novel fibrin sealant (Evicel, J&J) in patients undergoing primary TKA reduces peri-operative blood loss. Sixty-two patients were randomized to receive topical application of Evicel (N. = 31) or not (N. = 31). The mean total blood loss was 1.9. L(±. 0.7) in the control group and 1.8. L(±. 0.5) in the treatment group (P= 0.4). The transfusion rate was 32.3% in the control group and 25.8% in the treatment group (P= 0.5). The transfusion rate decreased linearly with increasing preoperative Hb levels in the treatment group (P= 0.005). The results of this study suggest that topical application of this novel fibrin sealant doesn't reduce perioperative blood loss and the need for allogeneic blood transfusion.
KW - Blood loss
KW - Fibrin sealants
KW - Total knee arthroplasty
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U2 - 10.1016/j.arth.2014.02.024
DO - 10.1016/j.arth.2014.02.024
M3 - Article
VL - 29
SP - 1516
EP - 1520
JO - Journal of Arthroplasty
JF - Journal of Arthroplasty
SN - 0883-5403
IS - 8
ER -